Process for producing acetylene compound

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Reexamination Certificate

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Reexamination Certificate

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07038091

ABSTRACT:
There is provided a process for producing an acetylene compound useful as an intermediate of pharmaceuticals, from 4-nitrofluorobenzene, in industrially and economically advantageous manner.Concretely, it is a method for producing an acetylene compound of formula (3)characterized by reacting 4-nitrofluorobenzene of formula (1)with an alkoxide of 2-methyl-3-butyn-2-ol of formula (2)at −20 to 10° C.

REFERENCES:
patent: 4542149 (1985-09-01), Evans et al.
patent: A 58-188880 (1983-11-01), None
Evans et al; “Synthesis and Antihypertensive Activity of Substituted trans-4-Amino-3, 4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols”; J. Med. Chem. 1983, pp. 1582-1589.
Bell et al; “Copper(I) Iodide: A Catalyst for the Improved Synthesis of Aryl Propargyl Ethers”; SYNTHESIS; Jun. 1995 pp. 707-712.
Godfrey et al; “Improved Synthesis of Aryl 1,1-Dimethylpropargyl Ethers”; Tetrahedron Letters, vol. 35, No. 35, 1994, pp. 6405-6408.
Subramanian et al; “A Facile Synthesis of Aryl Ethers of Ethynylcarbinols Using the Mitsunobu Reaction”; Synthetic Communications, 1989, pp. 1255-1259.
Harfenist et al; “The Influence of Structure on the Rate of Thermal Rearrangement of Aryl Propargyl Ethers to the Chromenes. The gem-Dimethyl Effect”; J. Org. Chem., vol. 37, No. 6, 1972, pp. 841-848.
Raeppel et al; “Novel Exploration of the SNAr Reaction”; SYNLETT; Apr. 14, 1998, pp. 794-796.
Xu et al; “Polymer Supported Bases in Combinatorial Chemistry: Synthesis of Aryl Ethers from Phenols and Alkyl Halides and Aryl Halides”; Tetrahedron Letters, vol. 38, No. 42, 1997, pp. 7337-7340.

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