4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives...

Details 4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives... 4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives...

2006-07-11

2006-07-11

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S317000, C546S192000, C546S207000

Reexamination Certificate

active

07074808

ABSTRACT:
Compounds of general formula I R1is selected from any one of phenyl, pyridinyl, pyrroloyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1phenyl ring and R1heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

REFERENCES:
patent: 2898339 (1959-08-01), Wheeler et al.
patent: 4581171 (1986-04-01), Kennis et al.
patent: 4816586 (1989-03-01), Portoghese
patent: 4939137 (1990-07-01), Russell et al.
patent: 5140029 (1992-08-01), Kennis et al.
patent: 5574159 (1996-11-01), Chang et al.
patent: 5683998 (1997-11-01), Shibayama et al.
patent: 6187792 (2001-02-01), Delorme et al.
patent: 6455545 (2002-09-01), Delorme et al.
patent: 6552036 (2003-04-01), Boyd et al.
patent: 6556387 (2003-04-01), Misso et al.
patent: 6756387 (2004-06-01), Brown et al.
patent: WO 93/15062 (1993-08-01), None
patent: WO 97/23466 (1997-07-01), None
patent: WO 98/28275 (1998-07-01), None
patent: WO98/28275 (1998-07-01), None
patent: WO 99/33806 (1999-07-01), None
patent: WO 0174804 (2001-10-01), None
patent: WO 0174806 (2001-10-01), None
Wei et al, N,N-diethyl-4-(phenylpiperidine-4-ylidenemethylObenzamide . . . J. Of Med. Chem. 2000, vol. 43, 3895-3905.
Bilsky, et al., SNC 80, A Selective, Nonpeptidic and Systemically Active Opioid Delta Agonist, J. Pharmacol. Experi. Ther. 273:359-366(1995).
Takemori, et al., “Selective Natrexone-Drived Opioid Receptor Antagonists,” Annu. Rev. Pharmacol. Toxicol. 32:239-269 (1992).
Barber, et al., “Antinociceptive Effects of the 5-HT Antagonist Ritanserin in Rats: Evidence for an Activation . . . in the Spinal Cord,” Neuroscience Letters 99:234-238 (1989).
Greene, “Protective Groups in Organic Synthesis,” Wiley & sons, pp. 218, 220, 232, 233, 251 (1982).
Wei, et al., “N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl) . . . and its Analogues,” J. Med. Chem. 43:3895-3905 (2000).
Zhang, et al., “Probes for Narcotic Receptor Mediated Phenomena. 26. 1-3 Synthesis . . . Opioid Receptor Ligands,” J. Med. Chem. 42:5455-5463 (1999).

Affiliated with

Also associated with

Rating

4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3586139