Human tumor suppressor gene

Details Human tumor suppressor gene Human tumor suppressor gene

2006-09-12

2006-09-12

Kaushal, Sumesh (Department: 1633)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S023400, C435S006120, C435S069100, C435S320100, C435S325000, C435S455000

Reexamination Certificate

active

07105652

ABSTRACT:
A novel human progestin-regulated gene designated EDD (E3 isolated byDifferentialDisplay) is disclosed which encodes a product exhibiting significant amino acid sequence identity with the HYD protein (hyperplastic discs) fromDrosophila melanogasterand the 100 kDa HECT (homologous toE6-APcarboxylterminus) domain protein from rat. The EDD gene appears to represent a tumour suppressor gene and the detection of a polymorphism or alteration in the gene from a subject may be useful for the diagnosis or determination of a predisposition to hyperproliferative disease such as a cancer. An assay for assessing progestin-responsiveness in a subject is also disclosed.

REFERENCES:
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