Thiocarbamate inhibitors of alpha-4 integrins

Details Thiocarbamate inhibitors of alpha-4 integrins Thiocarbamate inhibitors of alpha-4 integrins

2006-03-21

2006-03-21

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S173000, C544S176000, C544S389000, C544S383000, C544S161000, C546S244000, C546S147000, C546S015000, C546S309000, C548S531000, C549S439000

Reexamination Certificate

active

07015323

ABSTRACT:
The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1–R4, m, n, o and p are as defined herein. Also provided are compositions comprising compounds of formula I and a carrier, diluent or excipient as well as methods of treating a disease or condition mediated by the binding interaction of alpha-4 integrins to its ligands such as inflammatory diseases.

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