Vector constructs

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S320100, C435S455000, C435S456000, C435S235100, C435S366000, C424S093100, C424S093200, C424S093600, C536S063000, C536S023200, C536S023500, C536S023720, C536S024100

Reexamination Certificate

active

07109029

ABSTRACT:
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.

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