Bombesin analogs for treatment of cancer

Details Bombesin analogs for treatment of cancer Bombesin analogs for treatment of cancer

2006-01-24

2006-01-24

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S014800, C514S015800, C530S327000, C530S328000, C435S007100

Reexamination Certificate

active

06989371

ABSTRACT:
The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the design and synthesis of the novel peptides incorporating α,α-amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

REFERENCES:
patent: 5084555 (1992-01-01), Coy et al.
patent: 5217955 (1993-06-01), Bogden et al.
patent: 5369094 (1994-11-01), Schally et al.
patent: 5428019 (1995-06-01), Edwards et al.
patent: 5565431 (1996-10-01), Lipps et al.
patent: 5601992 (1997-02-01), Lerner et al.
patent: 5620955 (1997-04-01), Knight et al.
patent: 5620959 (1997-04-01), Leban et al.
patent: 5723578 (1998-03-01), Coy et al.
patent: 5834433 (1998-11-01), Krstenansky
patent: 6492330 (2002-12-01), Mukherjee et al.
patent: 2003/0050233 (2003-03-01), Burman et al.
patent: 0315367 (1989-05-01), None
patent: 0345990 (1989-12-01), None
patent: 0468497 (1992-01-01), None
patent: 0835662 (1998-04-01), None
patent: 0047221 (2000-08-01), None
Jaine, Sci. Amer., vol. 271, pp. 58-65, Jul 1994.
Curti, Critical Reviews in Oncology/Hematology, vol. 14, pp. 14-29, 1993.
Ross et al., Immunology Today, vol. 11, No. 6, 1990.
Simen, in Rodent Tumor Models in Experimental Cancer Therapy, edited by Robert F. Kallman, published by Pregamon Press, 1987, pp. 12-15.
Trott, in Rodent Tumor Models in Experimental Cancer Therapy, edited by Robert F. Kallma, published by Pregamon Press, 1987, pp. 6-11.
G. Halmos et al.; Characterization of Bombesin/Gastrin-Relating Peptide Receptors in Membranes of MKN45 Human Gastric Cancer; Cancer Letters 85 (1994) 111-118.
H. Reile et al.; Characterization of High-Affinity Receptors for Bombesin/Gastrin Releasing . . . Cells; The Prostate 25:29-38 (1994).
I. Zachary, et al.; Bombesin, Vasopressin, and Endothelin Rapidly Stimulate Tyrosine Phosphorylation in Intact Swiss 3T3 Cells; PNAS; vol. 88 pp. 4577-4581, Jun. 1991.
K. Szepeshazi et al.; Combination Treatment of Nitrosamine-Induced . . . Antagonist; Int'l. Journal of Pancreatology; vol. 16, Nos. 2-3, 141-149, Oct.-Dec. 1994.
K. Heiling et al.; Transforming Growth Factor . . . Colonic Epithelium; May 1986.
Frucht, et al.; Cancer Research 52 : 1114-1122, Mar. 1, 1992.
Willard R. Chappell, et al. “Extrapolation of Toxicological and Pharmacological Data From Animals to Humans” Advances in Drug Research, vol. 20 pp. 1-117.
Yuichi Sugiyama, et al. “Receptor-Mediated Disposition of Polypeptides: . . . ” Journal of Controlled Release, vol. 13 (1990) pp. 157-174 Elsevier Science Publishers B.V., Amsterdam.
Joyce Mordenti “Dosage Regimen Design For Pharmaceutical Studies Conducted in Animals” Journal of Pharmaceutical Sciences vol. 75, No. 9, Sep. 1986.
Harold Boxenbaum, et al. “First-Time-In-Human Dose Selection: Allometric Thoughts and Perspectives” Pharmacokinetics Series J. Clin Pharmacol 1995; vol. 35: pp. 957-966.

Affiliated with

Also associated with

Rating

Bombesin analogs for treatment of cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bombesin analogs for treatment of cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bombesin analogs for treatment of cancer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3581960