Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-01-31
2006-01-31
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S001110, C424S001650, C424S001810
Reexamination Certificate
active
06991777
ABSTRACT:
In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarized129Xe at a selected site(s) in selected environments in vivo. The gas exchange signal data can be used to evaluate: (a) the thickness of a barrier, such as a membrane, lining, wall or width of a lumen; (b) the operational condition or function of a membrane, body system or portion thereof; (c) cerebral perfusion; and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a disorder or disease, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat a disorder or disease.
REFERENCES:
patent: 5190744 (1993-03-01), Rocklage et al.
patent: 5352979 (1994-10-01), Conturo
patent: 5494655 (1996-02-01), Rocklage et al.
patent: 5509412 (1996-04-01), Bahn
patent: 5522390 (1996-06-01), Tuithof et al.
patent: 5545396 (1996-08-01), Albert et al.
patent: 5833947 (1998-11-01), Rocklage et al.
patent: WO 99/47940 (1999-09-01), None
Webber et al., Measuring Diffusion of Xenon in solution with hyperpolarized 129Xe NMR, 296 Chemical Physics Letters, p. 391-396, (Nov. 6, 1998).
Hou et al., Optimization of Fast Acquisition Methods for Whole-Brain Relative Cerebral Blood Volume (rCBV) Mapping with Susceptibility Contrast Agents, 9 J. Magnetic Resonance Imaging 233 (1999).
Simonsen et al., CBF and CBV Measurements by USPIO Bolus Tracking: Reproducibility and Comparison with Gd-Based Values, 9 J. Magnetic Resonance Imaging 342 (1999).
Swanson, et al., Distribution and Dynamics of Laswer-Polarized 129Xe Magnetization In Vivo, Magnetic Resonance in Medicine, pp. 1137-1145 (1999).
Lassen, Cerebral Transit of an Intravascular Tracer may Allow Measurement of regional Blood Volume but not Regional Blood Flow, 4 J. Cereb. Blood Flow and Metab. 633 (1984).
Belliveau et al., Functional Cerebral Imaging by Susceptibility-Contrast NMR, 14 Magnetic Resonance in Medicine 14 538 (1990).
Detre et al., Measurement of Regional Cerebral Blood Flow in Cat Brain Using Intracarotid 2H20 and 2H NMR Imaging, 14 Magnetic Resonance in Medicine 389 (1990).
Frank et al., Dynamic Dysprosium-DTPA-BMA Enhanced MRI of the Occipital Cortex; Functional Imaging in Visually Impaired Monkeys by PET and MRI (Abstract), Ninth Annual Scientific Meeting and Exhibition of the Society of Magnetic Resonance In Medicine (Aug. 18-24, 1990).
Ruppert et al., NMR of Hyperpolarized 129Xe in the Canine Chest: Spectral Dynamics During a Breath-Hold, 13 NMR in Biomedicine, p. 220-228 (2000).
Le Bihan, Magnetic Resonance Imaging of Perfusion, 14 Magnetic Resonance in Medicine 283 (1990).
Rosen et al., Perfusion Imaging by Nuclear Magnetic Resonance, 5 Magnetic Resonance Quarterly 263 (1989).
Maier T., et.al. Detection of Dissolved Hyperpolarized / sup 129/Xe in Human Brain, Proceedings of the International Society For Magnetic Resonance in Medicine, Sixth Scientifice Meeting and Exhibition, vol. 3, Apr. 1998, p. 1907.
Swanson S D, et.al. Brain MRI with Laser P larized 129 Xe, Magnetic Resonance in Medicine, Academic Press, Duluth, MN, US vol. 38, No. 5, Nov. 1, 1997, pp. 695-698.
Gao J-H, et.al. “Magnetization and Diffusion Effects in NMR Imaging of Hyperpolarized Substances” Magnetic Resonance in Medicine, Academic Press, Duluth, MN, US vol. 37, No. 1, 1997 pp. 153-158.
Peled S, et.al, “Determinants of tissue delivery for /sup129/Xe Magnetic Resonance in Humans” Magnetic Resonance in Medicine, Sep. 1996, Willimas & Wilkins, USA, vol. 36, No. 3, pp. 340-344.
Driehuys Bastiaan
Hall Margaret
Marelli Claudio
Chisholm Robert F.
Jones Dameron L.
Medi--Physics, Inc.
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