Process for the production of L-amino acids using strains of...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S115000, C435S106000

Reexamination Certificate

active

07052883

ABSTRACT:
The invention relates to a process for producing an L-amino acid, in particular, L-threonine, which comprises: cultivating a microorganism of the family Enterobacteriaceae producing the desired L-amino acid under conditions suitable for production of the amino acid, in which the fruR (cra) (fructose repressor) gene or nucleotide secluences coding therefor in the microorganism is attenuated, in particular are switched off or eliminated, and recovering the L-amino acid from the medium or in the cells of the microorganism.

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T. M. Ramseier, et al., Research in Microbiology, vol. 147, No. 6-7, pp. 489-493, “CRA and the Control of Carbon Flux via Metabolic Pathways”, Jul. 1996.
K. Jahreis, et al., Molecular and General Genetics, vol. 226, No. 1/2, pp. 332-336, “Nucleotide Sequence of theilvH-fruRGene Region ofEscherichia coliK12 andSalmonella typhimuriumLT2”, Apr. 1991.
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