Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2006-01-24
2006-01-24
Imam, Ali (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S407000, C600S413000, C600S476000, C600S478000, C600S310000, C356S303000, C356S432000, C250S459100, C250S461200
Reexamination Certificate
active
06990369
ABSTRACT:
The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases.
REFERENCES:
patent: 4582067 (1986-04-01), Silverstein et al.
patent: 4760840 (1988-08-01), Fournier, Jr. et al.
patent: 4770185 (1988-09-01), Silverstein et al.
patent: 4821116 (1989-04-01), Nagasaki et al.
patent: 5076825 (1991-12-01), Hayami et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5431158 (1995-07-01), Tirotta
patent: 5573531 (1996-11-01), Gregory
patent: 5590660 (1997-01-01), MacAulay et al.
patent: 5693043 (1997-12-01), Kittrell et al.
patent: 5776129 (1998-07-01), Mersch
patent: 5827190 (1998-10-01), Palcic et al.
patent: 5833683 (1998-11-01), Fuller et al.
patent: 5847832 (1998-12-01), Liskow et al.
patent: 5881195 (1999-03-01), Walker
patent: 5897562 (1999-04-01), Bolanos et al.
patent: 5910816 (1999-06-01), Fontenot et al.
patent: 6013053 (2000-01-01), Bower et al.
patent: 6086558 (2000-07-01), Bower et al.
patent: 6091984 (2000-07-01), Perelman et al.
patent: 6095982 (2000-08-01), Richards-Kortum et al.
patent: 6104939 (2000-08-01), Groner et al.
patent: 6108082 (2000-08-01), Pettipiece et al.
patent: 6537211 (2003-03-01), Wang et al.
patent: 6571118 (2003-05-01), Utzinger et al.
Arai et al., Aug. 1999,American Journal of Physiology, 277(2):H683-H697 “Myocardial oxygenation in vivo: optical spectroscopy of cytoplasmic myoglobin and mitochondrial cytochromes.”
Cui et al., Feb. 1992,IEEE Transactions on Biomedical Engineering, 39(2):194-201 “The Relationship of Surface Reflectance Measurements to Optical Properties of Layered Biological Media,”
Doornbos et al., Apr. 1999,Physics in Medicine&Biology, 44(4):967-981 “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy.”
Farrell et al., Jul./Aug. 1992,Medical Physics, 19(4):879-888 “A diffusion theory model of spatically resolved, steady-state diffuse reflectance for the noninvasive for the noninvasive determination of tissue optical properties in vivo.”
Gandjbakhche et al., Aug. 1999,American Journal of Physiology, 277(2):H698-H704 “Visible-light photon migration through myocardium in vivo.”
Wan et al.,Photochemistry and Photobiology, 34:493-499 “Analytical Modeling for the Optical Properties of the Skin with in vitro and in vivo Applications.”
Zeng et al., Feb. 1993,Physics in Medicine&Biology, 38(2):231-240 “A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies.”
Chernomordik Victor
Gandjbakhche Amir H.
Hattery David W.
Mulshine Jim
Smith Paul
Imam Ali
Jung William C.
Merchant & Gould P.C.
The United States of America as represented by the Department of
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