Chlorohydrin and hydroxycarboxylic ester asymmetric...

Details Chlorohydrin and hydroxycarboxylic ester asymmetric... Chlorohydrin and hydroxycarboxylic ester asymmetric...

2006-09-26

2006-09-26

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S069100, C435S320100, C435S252300, C435S252330, C435S325000, C435S146000, C435S252800, C536S023200, C536S023100

Reexamination Certificate

active

07112428

ABSTRACT:
The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived fromEnterobacter sp. DS-S-75 strain (FERM BP-5494) which is bacteria belonging to the genusEnterobacter, a EnHCH gene shown by base sequence of SEQ.ID.NO: 1, a gene encoding a protein having an amino acid sequence of SEQ.ID.NO: 2, andE. coliDH5α (pKK-EnHCH) deposited to International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology as a deposition No. FERM BP-08466.

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Sang Yup Lee and Young Lee, Appl Environ Microbiol,Jun. 2003; 69(6), 3421-3426.
Andrew Man Fai Liu, et al., Mapping the Substrate Selectivity of New Hydrolases Using Colorimetric . . . , Tetrahedron: Asymmetry, vol. 12, pp. 545-556, 2001.
Sakayu Shimizu, et al., Stereoselective Reduction of Ethyl 4-Chloro-3-Oxobutanoate . . . , Applied and Environmental Microbiology, pp. 2374-2377, Aug. 1990.

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