Method of inducing formation of kidney epithelia from...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S021800

Reexamination Certificate

active

07022666

ABSTRACT:
This invention provides methods of using a gp130 receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and to preserve kidneys for transplantation.

REFERENCES:
patent: 5202116 (1993-04-01), Brown et al.
patent: 0041713 (2000-07-01), None
Barasch, J. , L. Pressler, J. Connor, and A. Malik. 1996. A ureteric bud cell line induces nephrogenesis in two steps by two distinct signals.Am. J. Physiol.271: F50--F61.
Barasch, J. , J. Qioa, G. McWilliams, D. Chen, J.A. Oliver, and D. Herzlinger. 1997. Ureteric bud cells secrete multiple factors, including bFGF, which resue renal progenitors from apoptosis.Am. J. Physiol.273: F757-F767.
Barasch, J. , J. Yang, J. Qiao, P. Tempst, H. Erdjument-Bromage, W. Leung, J.A. Oliver. May, 1999. Tissue inhibitor of metallaproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros.J. Clin. Invest.103: 1299-1307.
Bard, J.B.L. and A.S.A. Ross. LIF, the ES-cell inhibition factor, reversibly blocks nephrogenesis in cultured mouse kidney rudiments. Development 113: 193-198, 1991.
Boccaccio, C., M. Ando, L.Tamagnone, A. Bardelli, P. Michieli, C. Battistini, and P.M. Comoglio. 1998. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.Nature391: 285-288.
Bonni, A., Y. Sun, M. Nadal-Vicens, A. Bhatt, D. A. Frank, I. Rozovsky, N. Stahl, G.D. Yancopoulos, and M.E. Greenberg. 1997. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.Science278: 477-483.
Grobstein, C. 1955. Inductive interaction in the development of the mouse metanephros.J. Exp. Zool.130: 319-339.
Gruenwald, P. 1943. Stimulation of nephrogenic tissue by normal and abnormal inductors.Anat. Rec.86: 321-335.
Hartner, A. et al. Cytokine-induced expression of leukemia inhibitory factor in renal mesangial cells. Kidney International 45: 1562-1571, 1994.
Hartner, A. et al. Renal mesangial cells have the capacity to synthesize and react to leukemia inhibitory factor. Ann. N.Y. Acad. Sci. 762 (Interleukin-6-Type Cytokines) : 424-425, 1995 (Abstract).
Herzlinger, D., J. Qiao, D. Cohen, N. Ramakrishna, and A.M.C. Brown, 1994. Induction of Kidney epithelial morphogenesis by cells expressing Wnt-l. Develop. Biol. 166: 815-818.
Karavanova, I.D., L.F. Dove, J.H. Resau, and A.O. Perantoni. 1996. Conditioned media from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme.Development122: 4159-4167.
Kispert, A., S. Vainio, A.P. McMahon. 1998. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney.Development125; 4225-4234.
Mayer, M., Bhakoo, K., and M. Noble. 1994. Ciliary Neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro.Development120: 143-153.
Morel, D.S. et al. Renal synthesis of leukemia inhibitory factor. Cytokine 12 (3) : 265-271, 2000 (Abstract).
Murphy, M., K. Reid, D.J. Hilton, and P.F. Bartlett. 1991. Generation of sensory neurons is stimulated by leukemia inhibitory factor.Proc. Natl. Acd. Sci.USA 88: 3498-3501.
Murphy, M., K. Reid, M.A. Brown, P.F. Bartlett. 1993 Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons.Development117: 1173-1182.
Murphy, M., K. Reid, M. Ford, J. B. Furness, and P. F. Bartlett. 1994. FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors,Development120: 3519-3528.
Perantoni, A.O., L.F. Dove and I. Karavanova. 1995. Basic fibroblast growth factor can mediate the early inductive events in renal development.Proc. Natl. Acad. Sci.USA. 92: 4696-4700.
Sariola, H., P. Ekblom, S. Henke-Fahle. 1989. Embryonic neurons as in vitro inducers of differentiation of nephrogenic mesenchyme.Devel. Biol.132: 271-281.
Stark, K., S. Vainio, G. Vassileva, A. P. McMahon. 1994. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated byWnt-4. Nature372: 679-683.
Taupin, J.L. et al. HILDA-LIF urinary excretion during acute kidney rejection. Transplantation 53 (3) : 655-658, 1992 (Abstract).
Wallner, E. I. et al. Growth factors in metanephric development. Renal Failure 20(2) : 331-341, 1998 (Abstract).

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