2,4-disubstituted thiazolyl derivatives

Details 2,4-disubstituted thiazolyl derivatives 2,4-disubstituted thiazolyl derivatives

2006-09-12

2006-09-12

Hui, San-Ming (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S367000, C514S368000, C514S388000, C514S387000, C514S394000, C514S393000, C514S396000

Reexamination Certificate

active

07105550

ABSTRACT:
This invention concerns the use of a compound of formula (I′)a N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form thereof, wherein Q is optionally substituted C3-6cycloalkyl, phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl; or Q is a radical of formulawherein X and Y each independently are O, NR3, CH2or S, with R3being hydrogen or C1-4alkyl; q is 1 to 4; Z is O or NR4with R4being hydrogen or C1-4alkyl; r is 1 to 3; L is optionally substituted phenyl or L is Het with Het being an optionally substituted five- or six-membered heterocyclic ring or an optionally substituted bicyclic heterocyclic ring; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through cytokines.

REFERENCES:
patent: 3459731 (1969-08-01), Gramera et al.
patent: 3406329 (1985-08-01), None
patent: 4029771 (1992-03-01), None
patent: 2022085 (1979-12-01), None
patent: 55-133366 (1980-10-01), None
patent: 62-067022 (1987-03-01), None
patent: 62-067023 (1987-03-01), None
patent: 62-108859 (1987-05-01), None
patent: 04-154773 (1992-05-01), None
patent: WO 92/16527 (1992-01-01), None
patent: WO 97/03073 (1997-01-01), None
patent: WO 97/18839 (1997-05-01), None
patent: WO 99/21555 (1999-05-01), None
patent: WO 99/32466 (1999-07-01), None
patent: WO 99/64418 (1999-12-01), None
patent: WO 00/17175 (2000-03-01), None
patent: WO 00/33837 (2000-06-01), None
Beers, M., The Merck Manual of Diagnosis and Therapy (17th ED) (1999), p. 302-305 and 416-417.
Chemical Abstracts, vol. 82, No. 5, Abstract No. 31289, 1975, XP-002151288.
Chemical Abstracts, vol. 83, No. 23, Abstract No. 193158, 1975, XP-002143922.
Chemical Abstracts, vol. 88, No. 15, Abstract No. 105204, 1978, XP-002151291.
Chemical Abstracts, vol. 89, No. 23, Abstract No. 197384, 1978, XP-002170057.
Chemical Abstracts, vol. 90, No. 9, Abstract No. 72098, 1979, XP-002151289.
Chemical Abstracts, vol. 94, No. 7, Abstract No. 47195, 1981, XP-002151292.
Chemical Abstracts, vol. 94, No. 17, Abstract No. 139797, 1981.
Chemical Abstracts, vol. 103, No. 7, Abstract No. 53986, 1985, XP002151290.
Chemical Abstracts, vol. 107, No. 8, Abstract No. 64874, 1987.
Chemical Abstracts, vol. 107, No. 8, Abstract No. 64875, 1987.
Chemical Abstracts, vol. 107, No. 21, Abstract No. 197776, 1987.
Chemical Abstracts, vol. 108, No. 25, Abstract No. 221648, 1988, XP002143924.
Chemical Abstracts, vol. 111, No. 3, Abstract No. 23457, 1989, XP-002143923.
Chemical Abstracts, vol. 117, No. 21, Abstract No. 212486, 1992.
Database Chemcats “Online” Accession No. 1998-629695; XP-002170058.
Batta A.K. et al., “Syntheses of 4-(2′-Thienyl)—And 4-(2′-Furyl)-Thiazoles.”Current Science, Fortnightly Journal of Research, 1970, pp. 417-418, vol. 39, No. 18.
Taurins A. et al., “Synthesis of Pyridyl-and Quinolyl-Substituted 2-Aminothiazoles (I).”J. Heterocyclic Chem., 1970, pp. 1137-1141, vol. 7, No. 5.
Sawhney S.N. et al., “Benzothiazole Derivatives: Part III. Synthesis and Antiinflammatory Activity of Some 2-(2-Amino-4-thiazolyl)-benzolthiazoles.”J. Indian Chem. Soc., 1974, pp. 566-568, vol. 51, No. 5.
Sawhney S.N. et al., “Synthesis and Antiinflammatory Activity of some 6-[2-Amino-(and substituted amino)-4-thiazoly] benzothlazoles.”J. Indian Chem.Soc., 1975, pp. 561-562, vol. LII, No. 6.
Westphal G.V. et al., “Synthesis of pyridylthlazoles.”P. Prakt. Chem., 1976, pp. 857-877, vol. 318, No. 5 (English Abstract provided).
Mandal A.K. et. “Studies on Dissociation Constants of Substituted Salicylic Acids in Ethanol-Water Mixtures by Conductometric Method.”J. Indian Chem. 1977, pp. 728-730, vol. 15A.
Singh S.P. et al., “TLC Seperation of Some Isomeric 2-and 6-[2-Amino (and substituted amino)-4-thiazolyl] Benzothiazoles.”Fresenius Z. Anal. Chem., 1977, p. 288, vol. 285.
Thakar K.A., “Synthesis of 2-(Substituted Anilino) 4-(Substituted Phenyl) thiazoles.”J. Pharm. Sci., 1978, pp. 587-589, vol. 67, No. 4.
Arya V.P. et al., “Isothiazoles: Part VIII* —Synthesis & Biological Activity of 4-(2-Amino-4-thiazolyl)isothiazoles.”Indian J. Chem., 1978, pp. 402-404, vol. 16B, No. 5.
Patil V.H. et al., “Synthesis of 2-Arylamino-4-[2′-(p-acetamido-benzenesulphonamido)-6′-benzothiazolyl] thiazoles & 2-Arylamino-4-(2′-sulphanilamido-6′-benzothiazolyl) thiazoles.”Indian J. Chem., 1979, pp. 519-521, vol. 17B, No. 2.
Upadhya K.G. et al., “Synthesis d Antiinflammatory Activity of 3-Substituted 4-(4′-Thiazolyl)-Sydnones.”Arch. Pharm.(Weinheim), 1980, pp. 684-688, vol. 313.
Metri J. et al., “Synthesis of New, Sulphamylanilino Substituted Thiazoles of Potential Biological Activity,”Egypt J. Chem.. 1982, pp. 187-189, vol. 25, No. 2.
Kapoor R.P. et al., “Synthesis of Thiazolylchromones as Potential CNS Agents.”Indian J. Chem., 1984, pp. 390-392, vol. 23B, No. 1.
Hanmantgad S.S. et al., “Biomimetic thiazolyt coumarins.”Natl. Acad. Sci. Letters, 1984, pp. 77-78, vol. 7, No. 3.
Nogradi M. “Dimethyl-β-Cyclodextrin.”Drugs of the Future, 1984, pp. 577-578, vol. 9, No. 8.
English Abstract of DE3406329, “New 2 (1H)-pyridone derivs. With positive inotropic activity—prepd. e.g. by reaction of 1,3-dioxo cpds. with acetamide or acetonitrile cpds,” 1985.
Khadse B.G. et al., “Synthesis & Antitubercular Activity of 4-(5-Nitro-2-furyl/2-pyrazinyl/1-adamantyl)-2-(alkyl/aryl/arylamino) thiazoles.”Indian J. Chem., 1987, pp. 856-860, vol. 26B, No. 9.
Sastry C.V.R. et al., “Synthesis & Biological Activity of Some New 6-Isothiocyanato-6, 6-N-[N,N-Bis(methoxycarbonyl) guanidine]-, & 6-(2-Aryl/2-arylaminothiazol-4-yl)-2H-1,4-benzoxazin-3(4H)-ones.”J. Indian Chem., 1987, pp. 662-685, vol. 26B.
Sawhney S.N., “Synthesis of some 2-Heterocyclylphenothiazines as Potential Anti-inflammatory Agents.”J. Indian Chem. Soc., 1988, pp. 643-647, vol. LXV.
Avetisyan A.A. et al., “Synthesis and activity of unsaturated γ-lactones with thiazoles fragments on the growth and development of vegetable crops.”Biol. Zh. Am. 1989, pp. 956-959, vol. 42, Nos. 9-10 (English Abstract provided).
Avetisyan A.A. et al., “Unsaturated lactones. Synthesis of δ-lactones with heterocyclic substituents.”Am. Khim. Zh., 1989, pp. 657-659, vol. 42, No. 10 (English Abstract provided).
English Abstract of DE4029771, “New N-hetero-aryl-2-nitroaniline derives.—useful as insecticides, acaricides and nematocides.” 1992.
English Abstract of WO92/16527, “New 2-substd. Pyridine derives. Useful as agricultural-horticultural bactericides—e.g. 2-(4-chlorobenzyl)-4-(6-methyl-2pyridyl) thiazole.” 1992.
Zohdi H. F. et al., “Reactions with Hydrazonoyl Halides, Part 20, Synthesis of New Unsymmetrical Azines, Dihydro-1,3,4-thiadiazoles and 5-Arylazothiazoles.”J. Chem Research(S), 1998, pp. 742-743.
Singh S.P. et al., “A Convenient Synthesis Of 4-(2-Furyl)-2-Substituted Thiazoles Utilising [Hydroxy (Tosyloxy) lodo] Benzene.”Synthethic Communications, 1998, pp. 2371-2378, vol. 28, No. 13.
International Search Report, PCT/EP01/01841, dated May 7, 2001 which relates to U.S. Appl. No. 10/220,350.

Affiliated with

Also associated with

Rating

2,4-disubstituted thiazolyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2,4-disubstituted thiazolyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,4-disubstituted thiazolyl derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3559016