Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-09-19
2006-09-19
Allen, Marianne P. (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S007100, C435S007200, C435S320100, C435S069100, C530S350000, C530S399000, C514S012200
Reexamination Certificate
active
07109030
ABSTRACT:
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
REFERENCES:
patent: 6391588 (2002-05-01), Andress et al.
patent: 6417330 (2002-07-01), Mascarenhas et al.
patent: 2003/0073622 (2003-04-01), Majumder et al.
patent: WO9429448 (1994-12-01), None
Hwa et al., “The insulin-like growth factor binding protein (IGFBP) superfamily” Endocrine Reviews 20:761-787 (1999).
Khandwala et al., “The effects of Insulin-like growth factors on tumotigenesis and neoplastic growth” Endocrine Reviews 21:215-244 (2000).
Komatsu et al., “Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen in transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M)” Biochem Biophys Res Commun 267:109-117 (2000).
Hwa er al., “Characterization of insulin-like growth factor-binding protein-related proetin-1 in prostate cells” J Clin Endocinol Metab 83:4355-4362 (1998).
Murphy et al., “Identification and characterization of genes differentially expressed in meningiomas” Cell Growth Different 4:715-722 (1993).
Swisshelm et al. “Enhanced expressionof an insulin growth factor-like binding protein (mac25) in senescent human mammary gland epithelial cells and induced expression with retionic acid” Proc Natl Acad Sci USA 92:4472-4476 (1995).
Wilson et al., “Insulin-like growth factor binding protein-related Protein-1 inhibits proliferation of mCF-7 breast cancer cells via a senescence-like mechanism” Cell Growth Differen 13:205-213 (2002).
Sprenger et al., “Insulin-like growth factor binding protein-related Protein-1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer” Cancer Res 59:2370-2375 (1999).
Burger et al. “Down-regulation of T1A12/mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas” Oncogene 16:2459-2467.
Henikoff et al., “Gene families: the taxonomy of protein paralogs and chimeras” Science 278:609-614 (1997).
Database GenBank; accession No. AB006141;Fujimoto et al.,; Direct Submission, Aug. 6, 1997.
Database Geneseq; accession No. AAR79102; Mizushima et al., First entry Nov. 13, 1995.
Asundi Vinod
Dedera Douglas A.
Drmanac Radoje T.
Liu Chenghua
Tang Y. Tom
Allen Marianne P.
Nuvelo, Inc.
Polizotto Renée S.
LandOfFree
Methods of therapy and diagnosis using insulin-like growth... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of therapy and diagnosis using insulin-like growth..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of therapy and diagnosis using insulin-like growth... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3557748