Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahy

Details Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahy Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahy

1986-10-16

1990-04-24

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544361, 546 71, C07D22118

Patent

active

049202219

ABSTRACT:
1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]-phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.

REFERENCES:
patent: 1915334 (1933-06-01), Salzberg et al.
patent: 4188495 (1980-02-01), Althuis et al.
patent: 4228169 (1980-10-01), Johnson et al.
patent: 4309545 (1982-01-01), Johnson
patent: 4595688 (1986-06-01), Marganoff
Wimmer et al., J. Org. Chem., vol. 40, No. 9, pp. 1198-1201 (1975).
Howlett et al., Chem. Abs., vol. 109, No. 1, Entry #217v, (1988).

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