Recombinant constructs of Borrelia burgdorferi

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide

Reexamination Certificate

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C424S009100, C424S009200, C424S184100, C424S185100, C424S190100, C424S234100, C530S300000, C530S350000

Reexamination Certificate

active

07008625

ABSTRACT:
Novel chimeric nucleic acids, encoding chimericBorreliaproteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.

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