Indole derivatives with vascular damaging activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S415000, C544S373000, C548S414000, C548S483000

Reexamination Certificate

active

07030123

ABSTRACT:
The invention provides a compound of Formula (I).Wherein R1, R2, R3, R10 and R11 have the meanings given in the description. Such compounds are predicted to cause the selective destruction of tumour vasculature. They may therefore be used to inhibit and/or reverse, and/or alleviate symptoms of angiogenesis and/or any disease state associated with angiogenesis.

REFERENCES:
patent: 3901914 (1975-08-01), Hannah
patent: 4533672 (1985-08-01), Eakin et al.
patent: 4952584 (1990-08-01), Thompson et al.
patent: 6147085 (2000-11-01), Horvath et al.
patent: 0 372 962 (1990-06-01), None
patent: 0 393 575 (1990-10-01), None
patent: 2000-80295 (2000-03-01), None
patent: WO 98/39323 (1998-09-01), None
patent: WO 99/29660 (1999-06-01), None
patent: WO 99/29661 (1999-06-01), None
patent: WO 99/51598 (1999-10-01), None
patent: WO 99/51600 (1999-10-01), None
patent: WO 00/48606 (2000-08-01), None
patent: WO 00/66585 (2000-11-01), None
patent: WO 01/19794 (2001-03-01), None
patent: WO 01/22954 (2001-04-01), None
patent: WO 01/29025 (2001-04-01), None
patent: WO 01/82909 (2001-11-01), None
Aleksandrzak, et al. Antimitotic Activity of Diaryl Compounds With Structural Features Resembling Combretastatin A-4. Anti-Cancer Drugs, 9, 545-550 (1998).
McGown, et al. Structural and Biochemical Comparison of the Anti-Mitotic Agents Colchicine, Combretastatin A4 and Amphethinile. Anti-Cancer Drug Design, 3, 249-254 (1989).
Galbraith, et al. Effects of Combretastatin A4 Phosphate on Endothelial Cell Morphology in Vitro and Relationship to Tumour Vascular Targeting Activity in Vivo. Anticancer Research, 21, 93-102 (2001).
Bolton, et al. Synthesis and Potential Anxiolytic Activity of 4-Amino-Pyrido[2,3-b]Indoles. Bioorganic & Medicinal Chemistry Letters, 3(10), 1941-1946 (1993).
Blackburn, et al. (+)11-Amino-2,6-Dimethyl-1,2,3,4-Tetrahydro-6H-Quinindolin-1-One, a Novel GabaA Modulator with Potential Anxiolytic Activity. Bioorganic & Medicinal Chemistry Letters, 4(2), 279-284 (1994).
McGown, et al. Pre-Clinical Studies of a Novel Anti-Mitotic Agent, Amphethinile. Br. J. Cancer, 57, 157-159 (1988).
McGown, et al. Interaction of the Novel Agent Amphethinile with Tubulin. Br. J. Cancer, 59, 865-868 (1989).
Newell, et al. Evaluation of Rodent-Only Toxicology for Early Clinical Trials with Novel Cancer Therapeutics. British Journal of Cancer, 81(5), 760-768 (1999).
Dark, et al. Combretastatin A-4, an Agent That Displays Potent and Selective Toxicity Toward Tumor Vasculature. Cancer Research, 57, 1829-1834 (1997).
Player, et al. Synthesis of 1,3-Disubstituted-2-amino-5-hydroxyindoles by Reductive Aromatization. J. Heterocyclic Chem., 30, 125-128 (1993).
Hess, et al. 7-Deazaadenines Bearing Polar Substituents: Structure-Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists. J. Med. Chem., 43, 4636-4646 (2000).
Fuse, et al. Application of Pharmacokinetically Guided Dose Escalation With Respect to Cell Cycle Phase Specificity. Journal of the National Cancer Institute, 86(13), 989-996 (1994).
Portnov, et al. Khim Gereotsikl Soedin, 3, 400-402 (1991).
Eger, et al. Synthesis of Substituted Indoles and Pyrimido[4,5-b]indoles by Dehydrogenation of Tetrahydroindoles and Tetrahydropyrimidoindoles. Liebigs Ann. Chem., 465-470 (1993).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Indole derivatives with vascular damaging activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indole derivatives with vascular damaging activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives with vascular damaging activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3546679

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.