Endothelial-monocyte activating polypeptide III antibodies

Details Endothelial-monocyte activating polypeptide III antibodies Endothelial-monocyte activating polypeptide III antibodies

2006-05-16

2006-05-16

Kemmerer, Elizabeth (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S387100, C530S387300, C530S387900, C530S388100, C530S388150, C530S388230, C530S388240, C530S389100, C530S389200, C530S391300, C435S326000, C435S328000, C435S331000, C435S335000, C435S336000, C435S346000

Reexamination Certificate

active

07045301

ABSTRACT:
A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

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Genbank Accession No. H10555,Hillier, et al., ym04e04.r1 Soares infant brain 1NIBHomo sapienscDNA clone IMAGE:46655 5′ similar to SP:SYM—THETH P23395 Methionyl-TRNA Synthetase, mRNA sequence (Jun. 23, 1995).
GenBank Accession No. AA327316, Adams, et al., “EST30628 Colon IHomo sapienscDNA 5′ end, mRNA sequence,” (Apr. 20, 1997).
GenBank Accession No. H13315, Hillier, et al., “y172b07.r1 Soares infant brain 1NIBHomo sapienscDNA clone IMAGE:43366 5′ similar to SP:SYYC—Yeast P36421 Tyrosyl-TRNA Synthetase, Cytoplasmic, mRNA sequence,” (Jun. 27, 1995).
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Kao, et al., “Characterization of a novel tumor-derived cytokine. Entothelial-monocyte activating polypeptide II,”J. Biol. Chem.,269(40):25106-25119 (1994).
Kao, et al., “Endothelial-monocyte activating polypeptides (EMAPs): tumor derived mediators which activate the host inflammatory response,”Behring Inst. Mitt.,92:920106 (1993).
Kao, et al., “Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms,”J. Biol. Chem.,267(28):20239-20247 (1992).
Kleeman, et al., “Human Tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine,”The Journal of Biologica

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