Sulfonation method for zonisamide intermediate in zonisamide...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07015330

ABSTRACT:
The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS—H) and its salts (BOS—Na, BOS—Ca, and BOS—Ba) and their novel preparation processes are disclosed.

REFERENCES:
patent: 4172896 (1979-10-01), Uno et al.
patent: 2002/0183525 (2002-12-01), Mendelovici et al.
patent: 2 428 033 (1980-01-01), None

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