Methods for the treatment and diagnosis of tumorigenic and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007100, C435S007210, C435S018000

Reexamination Certificate

active

07037668

ABSTRACT:
The present invention relates to methods and compositions for the treatment and diagnosis of tumorigenic and/or angiogenic disorders, including, but not limited to, lung tumors, breast tumors, ovary tumors, colon tumors, hemangioma, and metastatic and angiogenic tumors. The invention further provides methods for identifying a compound capable of treating a tumorigenic and/or angiogenic disorder or modulating tumorigenesis and/or angiogenesis. The invention also provides methods for modulating tumorigenesis and/or angiogenesis, e.g., modulating tumorigenesis and/or angiogenesis in a subject. In addition, the invention provides a method for treating a subject having a tumorigenic and/or angiogenic disorder characterized by aberrant 32616 polypeptide activity or aberrant 32616 nucleic acid expression.

REFERENCES:
patent: 6590075 (2003-07-01), Ruben et al.
patent: 1 067 182 (2000-07-01), None
patent: WO 00/05367 (2000-02-01), None
patent: WO 01/57190 (2001-08-01), None
Tang, Y.T., et al., “Nucleic Acids Encoding Polypeptides with Cytokine-Like Activities, Useful in Diagnosis and Gene Therapy,” Nov. 6, 2001, (sequence), EMBL Database [online], Hinxton, Cambridge, U.K., European Bioinformatics Institute, [retrieved on Oct. 20, 2004]. Retrieved from the Internet: URL: http://www.ebi.ac.uk/embl/>. EMBL Accession No. AAM79326.
Kato, S., et al., “Novel Human Proteins Having Hydrophobic Domains Useful for Treating Osteoporosis, alzheimer's Disease, Parkinson's Disease, Asthma, Multiple Sclerosis, Rheumatoid Arthritis, Cancer, Anemia, and Stroke,” Jun. 12, 2000, (sequence), EMBL Database [online], Hinxton, Cambridge, U.K., European Bioinformatics Institute, [retrieved on Oct. 20, 2004]. Retrieved from the Internet: URL: http://www.ebi.ac.uk/embl/>. EMBL Accession No. AAY94860.

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