Piperazine derivatives, their preparation and uses in therapy

Details Piperazine derivatives, their preparation and uses in therapy Piperazine derivatives, their preparation and uses in therapy

2006-09-19

2006-09-19

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S254090, C544S364000, C544S373000

Reexamination Certificate

active

07109201

ABSTRACT:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof are disclosed:in which Rais a group of formula (i)wherein P2is phenyl, naphthyl, heteroaryl or a 5 to 7 membered heterocyclic ring; P3is phenyl, naphthyl or heteroaryl; R1is NR4COR5, NR4SO2R5, CH2NR4SO2R5, CH2NR4COR5or CH2NR4CO2R5where R4and R5are independently hydrogen or C1-6alkyl; R2and R3are independently halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, COC1-6alkyl, haloC1-6alkyl, cyano or NR6R7where R6and R7are independently hydrogen or C1-6alkyl; b and c are independently 0, 1, 2 or 3; Y is a single bond, CH2or NH; W is —(CR9R10)t—where t is 2, 3 or 4 and R9and R10are independently hydrogen or C1-6alkyl or W is a group CH═CH; Rbis hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, COC1-6alkyl, cyano or C1-6alkoxy; and Rcis hydrogen or C1-6alkyl. Processes for preparation of the compounds and their uses in therapy, particularly depression, are also disclosed.

REFERENCES:
patent: WO 95/06637 (1995-03-01), None
patent: WO 98/50358 (1998-11-01), None
patent: WO 99/29666 (1999-06-01), None
patent: WO 01/23374 (2001-04-01), None
Gaster et al. Annual Reports in Medicinal Chemistry, vol. 33, p. 21-30 (1998).

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