Excitatory amino acid receptor modulators

Details Excitatory amino acid receptor modulators Excitatory amino acid receptor modulators

2006-07-25

2006-07-25

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S562000, C560S115000, C560S157000, C560S222000, C562S506000

Reexamination Certificate

active

07081481

ABSTRACT:
Compounds of the formula (I) in which: R1is (CH2)nY; n is 1 or 2; Y is NHSO2R2or X1—W—X2—R3; X1is O or NH; W is C═O, C═S, C═NH, or SO2; X2is O or NH, provided that X1and X2are not both O; R2is C1-10alkyl; C2-10alkenyl; C2-10alkynyl; aryl; aryl-C1-10alkyl; aryl-C2-10alkenyl; aryl-C2-10alkynyl; C3-8cycloalkyl or C3-8-cycloalkyl-C1-10alkyl; and R3is hydrogen, C1-10alkyl; C2-10alkenyl; C2-10alkynyl; aryl; aryl-C1-10alkyl; aryl-C2-10alkenyl; aryl-C2-10alkynyl; C3-8cycloalkyl; or C3-8-cycloalkyl-C1-10alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.

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Collado, Ivan et A., (2S,1'S,2′ R,3′R)-2-(2′-Carboxy-3′-hydroxymethylcyclopropyl) Glycine Is a Highly Potent Group 2 and 3 Metabotropic Glutamate Receptor Agonist with Oral Activity, J. Med. Chem, 2004, 456-466, vol. 47.
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