Nucleic acid molecules encoding modified factor VIII...

Details Nucleic acid molecules encoding modified factor VIII... Nucleic acid molecules encoding modified factor VIII...

2006-04-25

2006-04-25

Weber, Jon (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S006120, C435S320100, C435S252300, C536S023100, C536S023400, C530S350000, C514S002600, C514S012200

Reexamination Certificate

active

07033791

ABSTRACT:
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more amino acids of positions 484-508 of the A2 domain. The modified factor VIII is useful as a clotting factor supplement for hemophiliacs.

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