Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-01-17
2006-01-17
Murphy, Joseph (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C536S023500
Reexamination Certificate
active
06987004
ABSTRACT:
The present invention describes the identification, isolation, sequencing and characterization of two human CalDAG-GEF, and two human cAMP-GEF genes, which are associated with the Ras pathway. Also identified are CalDAG-GEF gene homologues in mice and cAMP-GEF gene homologues in rats. Nucleic acids and proteins comprising or derived from the CalDAG-GEFs and/or cAMP-GEFs are useful in screening and diagnosing certain Ras-associated cancers, in identifying and developing therapeutics for treatment of certain Ras-associated cancers, and in producing cell lines and transgenic animals useful as models of Ras-associated cancers.
REFERENCES:
patent: 4618598 (1986-10-01), Conn
patent: 4959313 (1990-09-01), Taketo
patent: 5874464 (1999-02-01), Marquez et al.
patent: WO 91/15515 (1991-10-01), None
patent: WO 98/53061 (1998-11-01), None
Eck, S.L. and Wilson, J. M. “Gene Based Therapy” in The Pharmacological Basis of Therapeutics, McGraw-Hill. 1996, pp. 77-101.
Bonaldo et al. Normalization and subtraction: two approaches to facilitate gene discovery. Genome research. 1996. vol. 6(9) 791-806.
Mehta et al. Identification of a Novel cis-Acting Element Participating in Maximal Induction of the Human Low Density Lipoprotein Receptor Gene Transcription in Response to Low Cellular Cholesterol Levels. Jpurnal of Biological Chemistry. vol. 271, No. 52.
Voet et al. Biochemistry. 1990. John Wiley and Sons, Inc. pp. 126-128 and 228-334.
Moreadith RW et al. Gene targeting in embryonic stem cells: the new physiology and metabolism. J Mol Med. Mar. 1997;75(3):208-16.
Seamark RF. et al. Progress and emerging problems in livestock transgenesis: a summary perspective. Reprod Fertil Dev. 1994;6(5):653-7.
Mullins LJ et al. Transgenesis in the rat and larger mammals. J Clin Invest. Apr. 1, 1996;97(7):1557-60.
Aklilu, F. et al.: “Induction of Parathyroid Hormone-related Peptide by the Ras Oncogene: Rose of Ras Farnesylation Inhibitors as Potential Therapeutic Agents for Hypercalcemia of Malignancy,”Cancer Research(Oct. 1997) v. 57, pp. 4517-4522.
Anderson, K.D. et al.: “Ciliary Neurotropic Factor Protects Striatal Output Neurons in an Animal Model of Huntington Disease,”Proc. Natl. Acad. Sci.(Jul. 1996) v. 93, pp. 7346-7351.
Bailey, C.H. et al.: “Toward a Molecular Definition of Long-Term Memory Storage,”Proc. Natl. Acad. Sci(Nov. 1996) v. 93, pp. 13445-13452.
Boguski, M.S. et al.: “Proteins Regulating Ras and its Relatives,”Nature(Dec. 1993) v. 366, pp. 643-654.
Bos, J.L. et al.: “In Search of a Function for the Ras-Like GTPase Rap1”FEBS(Mar. 1997) v. 410 pp. 59-62.
Burgering, B.M.T. et al.: “Regulation of Ras-Mediated Signalling: More Than One Way to Skin a Cat,”TIBS, (Jan. 1995) v.20, pp. 18-22.
Campbell, S.L. et al.: “Increasing Complexity of Ras Signaling”Oncogene, (1998) v. 47, pp. 4395-1413.
Chen, et al.: “A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II,”Neuron(May 1998) v.20, pp. 895-904.
Ebinu, J.O. et al.: “RasGRP, a Ras Guanyl Nucleotide-Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs.”Science, (May 15, 1998) v. 280, pp. 1082-1086, XP000882708.
Fiorillo, C.D. et al.: “Glutamate Mediates an Inhibitory Postsynaptic Potential in Dopamine Neurons”Nature(Jul. 1998) v. 394, pp. 78-82.
Fotuhi, M. et al.: “Phosphoinositide Second Messenger System is Enriched in Striosomes: Immunohistochemical Demonstration of Inositol 1, 4, 5-Trisphosphate Receptors and Phospholipase C β and γ in Primate Basal Ganglia”The Journal of Neuroscience(Aug. 1993) v. 13, No. 8, pp. 3300-3308.
Franke, B. et al.: “Rapid Ca2+-Mediated Activation of Rap1 in Human Platelets”The EMBO Journal(1997) v. 16, No. 2, pp. 252-259.
Gotoh, T. et al.: “Identification of Rapl as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G.”Molecular and Cellular Biology, (1995) v. 15, pp.. 6746-6753, XP000881340.
Heizman, C.W.: “Calcium-Binding Proteins: Basic Concepts and Clinical Implications”Gen. Physiol. Biophys.(1992) vol. 11, pp. 411-425.
Iyengar, R.: “Gating by Cyclic AMP: Expanded Role for an Old Signaling Pathway”Science(Jan. 1996) v. 271, pp. 461-463.
Kaibuchi, K. et al.: “Molecular Cloning of the cDNA for Stimulatory GDP/GTP Exchange Protein for smg p21s (ras p21-Like Small GTP-Binding Proteins) and Characterization of Stimulatory GDP/GTP Exchange Protein.”Molecular and Cellular Biology, (May 1991), v. 11, No. 5, pp. 2873-2880, XP000881341.
Kedra D. et al.: “The Germinal Center Kinase Gene and a Novel CDC25-Like Gene are Located in the Vicinity of the PYGM Gene on 11q13.”Hum Genet(Oct. 1997) v. 100, pp. 611-619, XP002069545.
Kedra D. et al.: “H. Sapiens mRNA for F25B.3 Kinase Like Protein FromC. Elegans.” AC Y12336, (Jun. 1997).
Kawasaki H. et al.: “A Rap Guanine Nucleotide Exchange Factor Enriched Highly in the Basal Ganglia.”Proc. Natl. Acad. Sci. USA, (Oct. 1998), v. 95, pp. 13278-13283, XP000882748.
Kim, J.H. et al.: “Syn GAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family”Neuron(Apr. 1998) v. 20, pp. 683-691.
Kitayama, H. et al.: “A ras-Related Gene with Transformation Suppressor Activity”Cell(1988) pp. 77-84.
Newton, A.C.: “Protein Kinase C: Structure, Function, and Regulation”The Journal of Biological Chemistry(Dec. 1995) v. 270, No. 48, pp. 28495-28498.
Overbeck, A.F. et al.: “Guanine Nucleotide Exchange Factors: Activators of Ras Superfamily Proteins”Molecular Reproduction and Development(1995) v. 42, pp. 468-476.
Renata, Z. et al.: “Ras-GRF, the Activator of Ras, is Expressed Preferentially in Mature Neurons of the Central Nervous System”Molecular Brain Research(1997) v. 48, pp. 140-144.
Santoro, B. et al.: “Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker channel of Brain”Cell(May 1998) v. 93, pp. 717-729.
Scholten, J.D. et al.: “Inhibitors of Farnesyl: Protein Transferase—A Possible Cancer Chemotherapeutic”Bioorganic&Medicinal Chemistry(1996) v.4, No. 9, pp. 1537-1543.
Silva, A.J. et al.: “A Mouse Model for the Learning and Memory Deficits Associate With Neurofibromatosis Type I”Nature Genetics(1997) v. 15, pp. 281-284.
Sturani, E. et al.: “The Ras Guanine Nucleotide Exchange Factor CDC25Mm is Present at the Synaptic Junction”Experimental Cell Research(1997) v. 235, pp. 117-123.
Vossler, M.R. et al.: “cAMP Activates MAP Kinase and Elk-1 Through a B-Raf- and Rap1-Dependent Pathway”Cell(1997) 73-82.
Walsh, D.A. et al.: “Multiple Pathway Signal Transduction by the cAMP-Dependent protein Kinase”The FASEB Journal(1994) v. 8 1227-1236.
York, R.D. et al: “Rap 1 Mediates Sustained MAP Kinase Activation Induce by Nerve Growth Factor”Nature(Apr. 1998) v. 392, pp. 622-626.
Zufall, F. et al: “Cyclic Nucleotide Gated Channels as Regulators of CNS Development and Plasticity”Current Opinion in Neurobiology(1997) v. 7, pp. 404-412.
Bos, J., (1998) “All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral”The EMBO Journal, vol. 17; No. 23, pp. 6776-6782.
Coller et al.,(1995) “New Antiplatelet Agents: Platelet GPIIb/IIIa Antagonists”Thrombosis and Haemostasis, vol. 74 (1), pp. 302-308.
Newman et al., (Jan. 1985) “Quantitation of Membrane Glycoprotein IIIa on Intact Human Platelets Using the Monoclonal Antibody, AP-3”Blood, vol. 65; No. 1, pp. 227-232.
De Bruyn, (Oct., 1974) “Rap1 and Ral in signal transduction; The Ras family: molecular switches in signaling cascades,”Ras-like small GTPases in platelet biology, University Medical Centre of Utrecht, The Netherlands, Chapter 1; General Introduction.
Zacharaski et al., (1990) “Chronic Calcium Antagonis
Graybiel Ann
Housman David
Kawasaki Hiroaki
Kirkpatrick & Lockhart Nicholson & Graham LLP
Massachusetts Institute of Technology
Murphy Joseph
LandOfFree
Genes integrating signal transduction pathways does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Genes integrating signal transduction pathways, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genes integrating signal transduction pathways will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3534208