N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosi

Details N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosi N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosi

1993-05-24

1996-06-11

Kight, III, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 268, 536 2762, 536 2781, 536 2851, 536 2853, 536 2534, C07H 19067, C07H 1910, C07H 19167, C07H 1920

Patent

active

055257194

ABSTRACT:
This invention is directed to processes for producing high purity N-protected-2'-O-methyl-5'-dimethoxytrityl-3' ribonucleoside methoxy, N,N-diisopropyl phosphoramidites (group 1), and N-protected-2'-O-methyl-5'-dimethoxytrityl-3'-ribonucleoside ethoxy, N,N-diisopropyl phosphoramidites (group 2). This invention is further directed to the process for producing high purity 2'-O-methyl-5'-dimethoxytrityl-inosine (structure IX; group 3), and 2'-O-methyl-5'-dimethoxytrityl-inosine-3'-cyanoethyl, N,N-diisopropyl phosphoramidite (structure Xa; group 3). This invention is also directed to the process for producing high purity N-protected-3'-O-methyl-5'-dimethoxytrityl ribonucleosides (group 6), and N-protected-3'-O-methyl-5'-dimethoxytrityl-2'-ribonucleoside cyanoethyl, N,N-diisopropyl phosporamidites (group 7).

REFERENCES:
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