Separation and counting of single molecules through...

Details Separation and counting of single molecules through... Separation and counting of single molecules through...

2006-04-25

2006-04-25

Noguerola, Alex (Department: 1753)

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

C204S601000, C204S600000

Reexamination Certificate

active

07033476

ABSTRACT:
An apparatus for carrying out the separation, detection, and/or counting of single molecules at nanometer scale. Molecular separation is achieved by driving single molecules through a microfluidic or nanofluidic medium using programmable and coordinated electric fields. In various embodiments, the fluidic medium is a strip of hydrophilic material on nonconductive hydrophobic surface, a trough produced by parallel strips of hydrophobic nonconductive material on a hydrophilic base, or a covered passageway produced by parallel strips of hydrophobic nonconductive material on a hydrophilic base together with a nonconductive cover on the parallel strips of hydrophobic nonconductive material. The molecules are detected and counted using nanoelectrode-gated electron tunneling methods, dielectric monitoring, and other methods.

REFERENCES:
patent: 6447663 (2002-09-01), Lee
patent: 6905586 (2005-06-01), Lee et al.

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