Methods for preparing pharmaceutical formulations

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C424S044000

Reexamination Certificate

active

06911455

ABSTRACT:
The invention relates to pharmaceutical formulations and methods for preparing pharmaceutical formulations of histamine releasers. The present invention provides methods for determining the concentration of physiologically acceptable excipients for use in the formulations of the invention. The present invention also provides methods for suppressing pharmaceutically-induced histamine release by administering to an animal, the formulations of the present invention. A kit useful for preparing pharmaceutical formulations of histamine releasers is also provided.

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Wien, R. “The Pharmacological Actions of Certain Aromatic Diamidines Possessing Trypanocidal Activity,” Ann. Trop. Med. Parasit (1943), 37.
MacIntosh, F.C., et al. “The Liberation of Histamine by Certain Organic Bases,” J. Physiol. (1949) 109, 190-219.
West, G.B. “Ethylenediamine Tetraacetic Acid and Histamine Release from Rat Mast Cells,” Int. Archs Allergy Appl. Immun. 68:399-401, 1982.
Read, G.W., et al. “Competitive Inhibition of 48/80-Induced Histamine Release by Benzalkonium Chloride and Its Analogs and the Polyamine Receptor in Mast Cells,” Journal of Pharmacology and Experimental Therapeutics, 1982, vol. 222, no.
Frisk-Holmberg, M., et al. “Histamine Release from Rat Peritoneal Mast Cells and Cat Paws Induced by Some Neuromuscular Blocking Agents,” ACTA Physiol. Scand. 1971, 81:367-375.
“Histamine Release by Drugs, Peptides, Venoms, and Other Agents,” Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, 1996, Chapter 25, pp. 583.

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