Process for preparing salmeterol

Details Process for preparing salmeterol Process for preparing salmeterol

2005-06-28

2005-06-28

Bart, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S346000

Reexamination Certificate

active

06911560

ABSTRACT:
Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxilary or hydrogen and P1and P2are each independently selected from hydrogen or a protecting group, which comprises: a) treatment of a compound of formula (II), or a salt or a solvate thereof, wherein W is a chiral auxilary and P3and P4are each independently selected from hydrogen or a protecting group, with a compound formula (III); b) treatment of the resulting product with a reducing agent; c) if required, deprotection to yield the compound of formula (I), or a salt or solvate thereof. In particular there is provided a process for producing a substantially pure single enantiomer of salmeterol

REFERENCES:
patent: 0422889 (1991-04-01), None
patent: 0460924 (1991-04-01), None
patent: 2140800 (1984-12-01), None
Hett, R., et. al., “Enantioselective Synthesis of Salmeterol via Asymmetric Borane Reduction”, 1994, pp. 9375-9378.

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