Use of vasopeptidase inhibitors in the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

active

06930103

ABSTRACT:
The invention describes and claims the use of vasopeptidase inhibitors of formula (I)for the treatment of nephropathy in diabetic or non-diabetic patients, including diabetic or non-diabetic nephropathy, glomerulonephritis, glomerular sclerosis, nephrotic syndome, hypertensive nephrosclerosis, microalbuminuria or end stage renal disease, or insulin resistance or of metabolic diseases associated with advanced glycation end-products, such as diabetic complications, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, myocardial infarction and/or diabetic cardiomyopathy, or atherosclerosis or endothelial dysfunction.

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Hofmann et al, RAGE Mediates a Novel Proinflammatory Axis: A Central Cell Surface Receptor for S100/Calgranulin Polypeptides, Cell., vol. 97, 1999, pp 889-901.
Bralet J et al., Vasopeptidase Inhibitors: an emerging class of cardiovascular drugs, TRENDS in Pharmacological Sciences, 22 (3), Mar. 2001, pp 106-109.
Kilhovd B et al., The ACE Inhibitor ramipril influences the serum levels of advanced glycation endproducts in high risk patients with coronary artery disease: results from a HOPE substudy, The European Society of Cardiology-XXII Congress, Sep. 1-5, 2001, Stockholm, Sweden, abstract 243.
Lewis Edmund J et al., The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy, N. England J. Med., 329, 1993, pp 1456-1462.
Molinaro Giuseppe et al., Vasopeptidase inhibitors: a new class of dual zinc metallopeptidase inhibitors for cardiorenal therapeutics, Curr. Opin. Pharmacol., 2002, 2, pp 131-141.
Singh R et al., Advanced glycation end-products: a review, Diabetologia, 44, 2001, pp 129-146.

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