Imidazole compounds and their use as adenosine deaminase...

Details Imidazole compounds and their use as adenosine deaminase... Imidazole compounds and their use as adenosine deaminase...

2005-06-21

2005-06-21

Shameem, Golam M M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S333500

Reexamination Certificate

active

06908940

ABSTRACT:
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1is aryloxy, or aryl which is optionally substituted with suitable substituent(s); R2is lower alkyl; R3is hydroxy or protected hydroxy; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

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G. Cristalli et al.: “Adenosine deaminase Inhibitors: structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogs” Drug Development Research, vol. 28, no. 3, pp. 253-258.
G. Cristalli et al.: “Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine” Journal of Medical Chemistry, vol. 34, no. 3, pp. 1187-1192 Mar. 1991.
C. Vargeese et al.: “Adenosine deaminase inhibitors, Synthesis and biological evaluation of putative metabolites of (+)-erythro-9-(2H-hydroxy-3R-nonyl) adenine” Journal of Medical Chemistry, vol. 37, no. 22, pp. 2844-2849 1994.

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