Process for producing optically active...

Details Process for producing optically active... Process for producing optically active...

2005-06-07

2005-06-07

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S375000, C435S123000, C435S170000

Reexamination Certificate

active

06903225

ABSTRACT:
This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions.A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprisesreacting an acetic acid derivative at a temperature of not less than −30° C. with an enolate prepared by permitting either a base or a metal having a valency of 0 to act on the derivative to produce a hydroxyoxohexanoic acid derivative,reducing this compound with the aid of a strain of microorganism to provide a halomethyldioxanylacetic acid derivative,treating this compound with an acetalizing agent in the presence of an acid catalyst to provide a halomethyl-dioxanylacetic acid derivative,reacted with an acyloxylating agent to provide a acyloxymethyldioxanylacetic acid derivative, andsubjecting this compound to solvolysis in the presence of a base.

REFERENCES:
patent: 4970313 (1990-11-01), Wess et al.
patent: 5155251 (1992-10-01), Butler et al.
patent: 5278313 (1994-01-01), Thottathil et al.
patent: 63-22056 (1988-01-01), None
patent: 05308977 (1993-11-01), None
patent: WO 97/00968 (1997-01-01), None

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