Apparatus for the preparation of a radioactive aqueous solution

Chemical apparatus and process disinfecting – deodorizing – preser – Chemical reactor – Bench scale

Reexamination Certificate

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C250S363030, C376S199000, C376S201000, C376S202000, C422S081000, C422S903000, C436S056000, C436S057000

Reexamination Certificate

active

06858187

ABSTRACT:
A device for preparing a radioactive water solution to be infused in a patient includes a reaction chamber (13) in which radioactive water vapour is formed by the catalysed reaction of oxygen gas containing oxygen-15 and hydrogen gas. A diffusion chamber (14) is provided which allows the radioactive water to penetrate, but which prevents the penetration of gasses. Tubes (26) and valves (16, 18) direct a sterile saline solution to the diffusion chamber (14), and then direct the saline solution containing radioactive water out from the diffusion chamber to a patient, or to a decay coil (22) being a part of the device. A measuring instrument is provided for measuring the radioactivity of the radioactive solution. The device is characterized in that the diffusion chamber (14), the tubes (26) the valves (16, 18), the radioactivity measuring instrument (17), and preferably also the reaction chamber913), are mounted in the same frame50, whereby they form a separate unit i.e. a water module (30), which as one entity can be detached from the lead shield (10) surrounding the device.

REFERENCES:
patent: 5082980 (1992-01-01), Berridge
patent: 5482865 (1996-01-01), Ferrieri et al.
patent: 0 486 283 (1992-05-01), None
Jones, S. C. et al, Nuclear Medicine and Biology Advances, Proc. World Congr., 3rd (1983), Meeting Date 1982, vol. 2, 2120-2124, Editor: Raynaud, Claude, Publisher: Pergamon, Oxford, UK.*
Robinson, G. D. Jr. Et al International Journal of Applied Radiation and Isotopes 1985, 36, 425-428.*
Goodman, M. M. et al, Journal of Labelled Compounds and Radiopharmaceuticals 1991, 30, 166-168.*
Jackson, J. R. et al, Applied Radiation and Isotopes 1993, 44, 631-634.*
Bradley et al, “An Automated [15O]H2O Production and Injection System for PET Imaging”,Nucl. Med. Biol.,vol. 22, No. 2, 1995, pp. 24-249. (no month).

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