24-cyclopropane vitamin D derivatives

Details 24-cyclopropane vitamin D derivatives 24-cyclopropane vitamin D derivatives

1992-07-08

1993-03-16

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552541, 552653, C01J17200, C01J 900, A61K 3159

Patent

active

051944316

ABSTRACT:
Vitamin D.sub.2 analogs in which a cyclopropane ring is introduced onto the 24-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and 1.alpha.-hydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxy-vitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desirbed, such as osteoporosis.

REFERENCES:
patent: 3833622 (1974-09-01), Babcock et al.
patent: 3901928 (1975-08-01), Hesse et al.
patent: 4225596 (1980-09-01), DeLuca et al.
patent: 4588716 (1986-05-01), DeLuca et al.
patent: 4769181 (1988-09-01), DeLuca et al.
patent: 4851401 (1989-07-01), DeLuca et al.
patent: 4973584 (1990-11-01), DeLuca et al.

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