Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-15
2005-11-15
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S276100, C548S379400
Reexamination Certificate
active
06965032
ABSTRACT:
This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II wherein R1, R2, R3, X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein R1, R2, R6, R7, R8and n are as defined in the disclosure. Also disclosed are certain intermediates of Formula 4 for the preparation of compounds of Formula I wherein X is N and R2, R3and n are as defined in the disclosure.
REFERENCES:
patent: 3153654 (1964-10-01), Ficken et al.
patent: 5945541 (1999-08-01), Sohn et al.
patent: 2003/0229050 (2003-12-01), Lahm et al.
patent: 0 333 131 (1989-09-01), None
patent: 9-17 6124 (1997-07-01), None
patent: 9-31 6055 (1997-12-01), None
patent: 9 202 078 (1994-06-01), None
patent: WO 01/70671 (2001-09-01), None
patent: WO 03/015519 (2003-02-01), None
patent: WO 03/016 282 (2003-02-01), None
U.S. Appl. No. 10/698,643, filed Oct. 31, 2003, Lahm et al.
U.S. Appl. No. 10/483,168, filed Jan. 7, 2004, Lahm et al.
U.S. Appl. No. 10/482,556, filed Dec. 30, 2003, Annis et al.
F. Foti et al., Tetrahedron Letters, First Synthesis of a Bromonitrilimine. Direct Formation of 3-Bromopyrazole Derivatives., 1999, vol. 40, pp. 2605-2605.
Donald J.P. Pinto et al., “Discovery of 1-[3-(Aminomethyl)phenyl)-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1”, J. Med. Chem., 2001, vol. 44, pp. 566-578.
M. V. Gorelik et al., “Structure and Properties of . . . ”, Journal of Organic Chemistry U.S.S.R. (English) 1985, 21, 773-781.
K. K. Bach et al., “1,3-Dipolar Cycloadditions of . . . ”, Tetrahedron 1994, 50(25), 7543-7556.
J. P. Chupp, “New Regional Isomers of . . . ”, J. Heterocyclic Chem. 1994, 31, 1377-1380.
E. I. du Pont de Nemours and Company
Freistein Andrew B.
McKane Joseph K.
LandOfFree
Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3502165