Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-09-07
1991-05-28
Rose, Shep K.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
128804, 424423, 424424, 424426, 424462, 424450, 424451, 424453, 424470, 424496, 424499, 6048901, 6048911, A61K 900, A61K 916, A61L 1503
Patent
active
050193724
ABSTRACT:
A magnetically responsive composition for the modulated, sustained administration of a biologically active substance, the composition being in the form of a body sized and shaped for placement in the environment of use, the environment including an aqueous fluid, the body comprising, in admixture, a first phase comprising a biocompatible, plastically deformable, polymeric matrix, the polymeric matrix being insoluble in the environment of use, a second phase having a biologically active substance distributed throughout the matrix to be released to the aqueous fluid outside the matrix, and a third phase comprising a magnetically responsive substance encapsulated within the matrix so that, upon exposure of the body to an oscillating magnetic field, the rate of release of the biologically active substance to the aqueous fluid is increased.
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Langer et al. J. Membrane Sci. 7: 333-350 (1980) Control of Release Kinetics of Macromolecules from Polymers.
Hsieh et al. Proc. Natl. Acad. Sci. U.S.A. 78(3): 1863-1867, Mar. 1981, Magnetic Modulation of Release of Macromolecules from Polymers.
Langer, Chemtech Feb. 1982, pp. 98-105 Controlled Release of Macromolecules.
Folkman Judah
Hsieh Dean S. T.
Langer, Jr. Robert S.
Rose Shep K.
The Children's Medical Center Corporation
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