Process for producing...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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06965031

ABSTRACT:
A process for producing a compound represented by the following formula (IV):(wherein R denotes a hydrogen atom, an alkyl group, or an aryl group), comprising reducing a compound selected from the group consisting of:a compound represented by the following formula (I):(wherein R is as defined in the formula);a compound represented by the following formula (II):(wherein R is as defined in the formula); anda compound represented by the following formula (III):(wherein R is as defined in the formula), by reacting the compound with a cell of a microorganism and/or a cell preparation thereof capable of stereo-selectively reducing a keto group.

REFERENCES:
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patent: 8-92217 (1996-04-01), None
patent: 8-127585 (1996-05-01), None
patent: 11-507204 (1999-06-01), None
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Barry Lygo, “N-Acyl-2-methylaziridines: Synthesis and Utility in the C-Acylation of β-Ketoester Derived Dianions”, Tetrahedron, vol. 51, No. 47, pp. 12859-12868, 1995.
James S. Hubbard et al., “Condensations at the 6 Position of the Methyl Ester and the Dimethylamide of 3,5-Dioxohexanoic Acid via 2,4,6-Trianions”, J. Org. Chem., vol. 46, No. 12, pp. 2566-2570, 1981.
S. Nagamatsu et al., “Chiral separation of a pharmaceutical intermediate by a simulated moving bed process”, Journal of Chromatography A, 832, 55-65, (1999).
A. Shafiee et al., “Purification, characterization and immobilization of an NADPH-dependent enzyme involved in the chiral specific reduction of the keto ester M, an intermediate in the synthesis of an anti-asthma drug, Montelukast, from Microbacterium campoquemadoensis (MB5614)”, Appl. Microbiol Biotechnol, 49, pp. 709-717, 1998.
Biswanath Das et al., “The First Conversion of Camptothecin To (S)-Mappicine By An Efficient Chemoenzymatic Method”, Bioorganic & Medicinal Chemistry Letters, 8, pp. 1403-1406, 1998.
Ramesh N. Patel et al., “Enantioselective microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic acid, ethyl ester”, Enzyme Microb. Technol., vol. 15, pp. 1014-1021, 1993.

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