Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2005-06-14
2005-06-14
Leary, Louise N. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
C435S015000, C435S008000, C435S069200, C435S069100, C530S300000
Reexamination Certificate
active
06905836
ABSTRACT:
Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated IκB by interfering, directly or indirectly, with the ability of β-TrCP/E3RS to engage in protein-protein association involving hnRNP-U, are useful as drugs for treating conditions associated with NF-κB activation. Cellular and non-cellular screening methods for identifying such compounds are based on monitoring the association/dissociation of β-TrCP/E3RS.
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Alkalay-Snir Irit
Ben-Neriah Yinon
Davis Matti
Hatzubai Ada
Shushan Etti Ben
Frommer William S.
Frommer & Lawrence & Haug LLP
Leary Louise N.
Yissum Research Development Company of the Hebrew University of
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