Phytochemotherapy for cancer

Details Phytochemotherapy for cancer Phytochemotherapy for cancer

2005-02-01

2005-02-01

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C424S725000, C424S774000

Reexamination Certificate

active

06849604

ABSTRACT:
The present invention provides for a novel anti-neoplastic pharmaceutical composition. Specifically, the present invention provides for phytochemotherapeutic compositions produced from aqueous extracts (and fractions thereof), derived fromVernonia amygdalinaleaves. These pharmaceutical compositions inhibit the growth of neoplastic cells, including human breast cancer cells. Furthermore, the instant invention provides for methods of producing the compositions and methods of using the compositions to inhibit the proliferation of neoplastic cells.

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patent: 6016550 (1994-01-01), None
patent: 6192265 (1994-07-01), None
Kupchan, S.M., Hemingway, R.J., Kamin, A., and Werner, D. “Tumor inhibitors. XLVII vernodalin and vernomygdin, two new cytotoxin sesquiterpene lactones fromVernonia amygdalinaDel.”J. Org. Chem. 34:3908-3911 (1969).
Jisaka, M., Ohigashi, H., takegawa, K., Huffman, M.A., and Koshimizu, K. “Antitumoral and antimicrobial activities of bitter sesquterpene lactones ofVernonia amygdalina, a possible medicinal plant used by wild chimpanzees,”Biosci. Biotech. Biochem. 57:833-834 (1993).
Ojukwu et al.,Bull. Anim. Health Prod. Afr., 30(3):257-260. 1982 (VETU abstract).
Almagboul et al.,Fitoterapia, 59(5):393-396, 1988.
Obatomi et al.,Phytother. Res., 11:171-173.

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