Method for diagnosing nephropathy

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S174000, C435S287100, C435S287700, C435S288700, C422S161000, C422S164000, C422S169000, C422S172000

Reexamination Certificate

active

06969591

ABSTRACT:
Means of conveniently examining nephropathy; and a method of assaying substance(s) in association with nephropathy (for example, podocalyxin and/or nephrin) in the urine to be used in the above means. The above assay method can be provided by releasing proteins in association with nephropathy, which exist on the surface of podocytes, from the cell surface and thus assaying the substances existing on the cell surface and/or free substances contained in the urine.

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Hara et al., Immunohistochemical and urinary markers of podocyte injury. 1998. Pediatric Nephrology, 12:43-48.
Hara et al., Urinary excretion of podocytes reflects disease activity in children with glomerulonephritis. 1998. American Journal of Nehprology, 18:35-41.
International Search Report for PCT/JP01/08512.

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