Pharmaceutical excipient having improved compressibility

Details Pharmaceutical excipient having improved compressibility Pharmaceutical excipient having improved compressibility

2005-02-22

2005-02-22

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S400000, C424S464000, C424S465000, C424S489000, C424S490000, C106S154110

Reexamination Certificate

active

06858231

ABSTRACT:
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

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Machines Collette High Shear Mixer Granulator Promotional Literature, date unknown.

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