Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Reexamination Certificate
2005-02-15
2005-02-15
Badio, Barbara P. (Department: 1616)
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
Reexamination Certificate
active
06855837
ABSTRACT:
The invention relates to a process for the preparation of stanol esters by hydrogenating a sterol blend in a hydrogenation solvent and at an elevated temperature in the presence of a hydrogenation catalyst, by removing the hydrogenation catalyst from the obtained hot reaction solution, by transesterifying the intermediate stanol blend with a fatty acid methyl ester at an elevated temperature and in the presence of a transesterification catalyst, and by finally purifying the stanol ester blend thus obtained. According to the invention, the intermediate stanol blend is neither crystallized nor removed from the reaction solution but the hydrogenation solvent is replaced therein at least in part by a transesterification reagent. Alternatively, the hydrogenation solvent may also be used as the transesterification solvent, and preferably also as the transesterification reagent.
REFERENCES:
patent: 4428885 (1984-01-01), Higaki et al.
patent: 5502045 (1996-03-01), Miettinen et al.
patent: 0 911 385 (1999-04-01), None
patent: 9219640 (1992-11-01), None
patent: 9801126 (1998-01-01), None
patent: 9806405 (1998-02-01), None
patent: 21 01 967616 (1998-05-01), None
Sugano et al., “Lipid-Lowering Activity of Phytostanols in Rats.” Atherosclerosis, vol. 24, pp. 301-309, 1976.*
Augustine et al., “The Palladium Catalyzed Hydrogenation of Cholesterol.”, Organic Preparations and Procedures, vol. 1(2), pp. 107-109, 1969.*
Declaration by Ilkka Etupaltta, Jan. 18, 2001.
Serum Plant Sterols and Cholesterol Precursors Reflect Cholesterol Absorption and Synthesis in Volunteers of a Randomly Selected Male Population, Miettinen et al., Am. J. Epiderm., vol. 131, No. 1:20-31, 1990.
Fate of Dietary Sterols in Hydrogenated Oils and Fats, P.W. Parodi, J.Am. Oil Chem. Soc., vol. 52:345-348, 1975.
Saturated Sterols(Stanols)in Unhydrogenated and Hydrogenated Edible Vegetable Oils and in Cereal Lipids, Dutta et al., J. Sci. Food Agric., vol. 17:383-391, 1996.
Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet, Eur. J. Clin. Nutrition, vol. 54, 715-725, 2000.
Effects of Low-Fat Yogurt with Plant Stanol Esters and of Consumption Frequency on LDL-Cholesterol Levels, J. Plat et al., Summary of Presentation at 92nd AOCS Annual Meeting and Expo, May 13-16, 2001, Minneapolis, Minnesota, USA.
Front page of WO 92/19640, Nov. 12, 1992.
PCT Applicant's Guide (Swedish Patent Office as ISA), Jul. 1999.
PCT Applicant's Guide (Sweidsh Patent Office as IPEA), Jul. 1998.
Efficacy of spreads enriched with stanol-stearate esters on blood cholesterol levels, Annex I filed with the Opponent's further submissions of Jun. 27, 2000.
Stanol Components in Edible Fats and Oils, M. Sugano et al., Sci. Byull. Fac. Agr. Kyushu Univ., vol. 32, No. 1:21-28, 1977.
Ullmann's Encyclopedia of Industrial Chemistry, vol. A16:152-153, 1990.
Elintarvike-tekniikan Perusteet, M.Hiros et al., VAPK-kustannus, Helsinki, 1990, * translation of passage bridging pp. 240-241.
Hydrogenation of sterol esters. Demonstration of hydrogenation of sterol moiety, Annex II filed with the Opponent's further submission of Jun. 27, 2000.
Augustine et al., “The Palladium Catalyzed Hudrogenation of Cholesterol”, Organic Preparations and Procedures 1(2), 107-109 (1969).
Sugano et al., “Lipid-Lowering Activity of Phytostanols in Rats”, Atherosclerosis, 24 (1976) 301-309.
Arent & Fox PLLC
Badio Barbara P.
Raisio Benecol Ltd.
LandOfFree
Process for the preparation of stanol esters does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of stanol esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of stanol esters will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3483830