Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-08-30
2005-08-30
Kemmerer, Elizabeth (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S399000, C424S085100
Reexamination Certificate
active
06936582
ABSTRACT:
OP/BMP morphogen is combined with GDNF/NGF neurotrophic factors in promoting the survival or growth, or inhibiting the death or degeneration, of mammalian cells, particularly neural cells, which express OP/BMP-activated serine/threonine kinase receptors and GDNF/NGF-activated tyrosine kinase receptors. Also discosed are methods for the treatment of such cells, including treatments for mammals afflicted with, or at imminent risk of, damage or injury to, such cells, as well as new pharmaceutical preparations for such treatments.
REFERENCES:
patent: 5851832 (1998-12-01), Weiss et al.
patent: 6294346 (2001-09-01), Weiss et al.
patent: WO 92/000392 (1992-01-01), None
patent: WO 96/18735 (1996-06-01), None
patent: WO 97/21447 (1997-06-01), None
Trupp et al. Peripheral Expression and Biological Activities of GDNF, a New Neurotrophic Factor for Avian and Mammalian Peripheral Neurons. The Journal of Cell Biology vol. 130/1 137-148 (Jul. 1995).
Jackowski, A. Neural injury repair: hope for the future as barriers to effective CNS regeneration become clearer. British Journal of Neurosurgery 9:303-317 (1995).
Buckel, P. Recombinant proteins for therapy. TiPS vol. 17 pp. 450-456 (Dec. 1996).
Durbec et al. GDNF signalling through the Ret receptor tyrosine kinase. Nature vol. 381 789-793 (Jun. 27, 1996).
Lein et al. The Effects of Extracellular Matrix and Osteogenic Protein-1 on the Morphological Differentiation of Rat Sympathetic Neurons. Int. J. Devl. Neuroscience vol. 14 No. 3 203-215 (1996).
Bengtsson et al. Potentiating Interactions Between Morphogenetic Protein and Neurotrophic Factors in Developing Neurons Journal of Neuroscience Research 53:559-568 (Sep. 1, 1998).
Wells JA Additivity of Mutational Effects in Proteins. Biochemistry 29:8509-8517 (1990).
Ngo et al. Computational Complexity, Protein Structure Prediction and the Levinthal Paradox. The Protein Folding Problem and Tertiary Structure Prediction. 492-495 Birkhauser Boston (1994).
Freshney, R I Culture of Animal Cells. A Manual of Basic Technique. Alan R. Liss, Inc. New York, (1983).
Batchelor, P.E. et al. Nerve Growth Factor Receptor and Choline Acetyltransferase Colocalization in Neurons within the Rat Forebrain: Response to Fimbrian-Fornix Transection.J. Comp. Neurol.284, 187-204 (1989).
Beck et al. The Nature of the Trophic Action of Brain-Derived Neurotrophic Factor, des(1-3)-Insulin-Like Growth Factor-1, and Basic Fibroblast Growth Factor on Mesencephalic Dopaminergic Neurons Developing Culture,Neurosci.52, 855-866 (1993).
Bengtsson, H. et al. Potentiating Interactions Between Morphogenetic Protein and Neurotrophic Factors in Developing Neurons.J. Neurosci. Res.53, 559-568 (1998).
Berkemeier et al. Neurotrophin-5: A Novel Neurotrophic Factor that Activates trk and trkB.Neuron7, 857-866 (1991).
Bruckenstein, D.A. & Higgins, D. Morphological Differentiation of Embryonic Rat Sympathetic Neurons in Tissue Culture.Dev. Biol.128, 324-336 (1988).
De Koninck, P. et al. NGF Induces Neonatal Rat Sensory Neurons to Extend Dendrites in Culture after Removal of Satellite Cells.J. Neurosci.13, 577-585 (1993).
Durbec, P. et al. GDNF signaling through the Ret receptor tyrosine kinase.Nature381, 789-793 (Jun. 27, 1996).
Ebendal, T. Function and Evolution in the NGF Family and its Receptors.J. Neurosci. Res.32, 461-470 (1992).
Ernfors, P. et al. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: Developmental and topographical expression in the brain.PNSA87, 5454-5458 (Jul. 1990).
Hallbook, F. et al. Neurotrophins and their receptors in chicken neuronal development.Int. J. Dev. Biol.39, 855-868 (1995).
Hefti, F. Neurotrophic Factor Therapy for Nervous System Degenerative Diseases.J. Neurobiol.25, 1418-1435 (1994).
Hoffer et al. Glial cell-line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo.Neurosci. Letters182, 107-111 (1994).
Hudson, J. et al. Glial Cell Line-derived Neurotrophic Factor Augments Midbrain Dopaminergic Circuits in Vivo.Brain Res. Bull.36, 425-432 (1995).
Hyman et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.Nature350, 230-232 (1991).
Ibanez, C. F. et al. Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion.Development117, 1345-1353 (1993).
Ip, N.Y. et al. Mammalina neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity.PNAS89, 3060-3064 (Apr. 1992).
Knusel, B. et al. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.PNAS88, 961-965 (Feb. 1991).
Lein, P. et al. The Effects of Extracellular Matrix and Osteogenic Protein-1 on the Morphological Differentiation of Rat Sympathetic Neurons.Int. J. Dev. Neurosci.14, 203-215, (1996).
Lein, P. et al. Osteogenic Protein-I Induces Dendritic Growth in Rat Sympathetic Neurons.Neuron15, 597-605 (Sep. 1995).
Lin, L.-F. H. et al. GDNF: A Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons.Science260, 1130-1132 (1993).
Liu, F. et al. Human Type II REceptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs.Mol. Cell. Biol.15, 3479-3486 (Jul. 1995).
Lomko, I. Neurotrophins—An Update.DN&P6, 669-671 (Nov. 1993).
Nostrat et al. Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system.Cell Tiss. Res.286, 191-207 (1996).
Olson, L. Neurotrophins in Neurodegenerative Disease: Theoretical Issues and Clinical Trials.Neurochem. J.25, 1-3 (1994).
Oppenheim et al. Developing motor neurons rescued from programmed and axotomy-induce cell death by GDNF.Nature373:344-346 (1995).
Pachnis, V. et al. Expression of the c-ret proto-oncogene during mouse embroygenesis.Development119, 1005-1017 (1995).
Pei & Enbendal. Specific Lesions in the Extrapyramidal System of the Rat Brain Induced by 3-Nitropropionic Acid (3-NPA).Exp. Neurol.132, 105-115 (1995).
Rosenzweig, B.L. et al. Cloning and characterization of a human type II receptor for bone morphogenetic proteins.PNAS92, 7632-7636 (Aug. 1995).
Sauer et al. Brain-derived neurotrophic factor enhances function rather than survival of intratriatal dopamine cell-rich grafts.Brain Res.626, 37-44 (1993).
Schuchardt, A. et al. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptory Ret.Nature367, 380-383 (1994).
Snider, W.D. & Johnson, E.M. Neurotrophic Molecules.Ann. Neurol.26, 489-506 (1989).
Snider, W.D. Nerve Growth Factor Enhances Dendritic Arborization of Sympathetic Ganglion Cells in Developing Mammals.J. Neurosci.8, 2628-2634 (1988).
Soderstrom, S. et al. Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain.Cell Tiss. Res.286, 269-279 (1996).
Soderstrom, S. et al. The effect of mercury vapour on cholinergic neurons in the fetal brain: studies on the expression of nerve growth factor and its low- andn high-affinity receptors.Dev. Brain Res.85, 96-108 (1995).
Tropea, M. et al. Glial Cells Promote Dendritic Development in Rat Sympathetic Neurons in Vitro.Glia1, 380-392 (1988).
Trupp, M. et al. Functional receptor for GDNF encoded by the c-ret proto-oncogene.Nature381, 785-789 (1996).
Vasquez, M.E. & Ebendal, T. Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain.Neuro Report2, 593-596 (1991).
Williams, R. & Ebendal, T. Neurotrophin receptor expression during development of the chick spinal sensory ganglion.Neuro Report6, 2277-2282 (1995).
Williams, R. et al. Developmentally Regulated Expression of mRNA for Neurotrophin High-Affinity (trk) Receptors within Chick Trigeminal Sensory Neurons.Eur. J. Neurosci.7, 116-128 (1995).
Yan et al. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons.Nature373, 341-344 (1995).
Jones et al., 1991, “Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogene
Charette Marc F.
Ebendal Ted
Rueger David C.
Curis, Inc.
DeBerry Regina M.
Kemmerer Elizabeth
Ropes & Gray LLP
LandOfFree
Synergistic effects of OP/BMP morphogens and GDNF/NGF... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synergistic effects of OP/BMP morphogens and GDNF/NGF..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synergistic effects of OP/BMP morphogens and GDNF/NGF... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3481902