Oligonucleotide analogs having modified dimers

Details Oligonucleotide analogs having modified dimers Oligonucleotide analogs having modified dimers

2005-02-01

2005-02-01

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S024300, C536S025300

Reexamination Certificate

active

06849723

ABSTRACT:
Modified dimers having a ribose sugar moiety in the 5′ nucleoside and a 2′ modified sugar in the 3′ nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.

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