Method for treating primary hyperparathyroid disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C436S500000

Reexamination Certificate

active

06974793

ABSTRACT:
A method for treating hypoparathyroidism and/or hypocalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a parathyroid gland, thereby reducing an inhibitory effect upon parathyroid hormone secretion. A method for treating hyperparathyroidism and/or hypercalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates a parathyroid hormone secreting parathyroid cell, thereby reducing a stimulatory effect upon parathyroid hormone secretion.

REFERENCES:
patent: 5667808 (1997-09-01), Johnson et al.
patent: 5674205 (1997-10-01), Pasricha et al.
patent: 5766605 (1998-06-01), Sanders et al.
patent: 5980945 (1999-11-01), Ruiz
patent: 6007843 (1999-12-01), Drizen et al.
patent: 6011011 (2000-01-01), Hageman
patent: 6022554 (2000-02-01), Lee et al.
patent: WO94/21300 (1994-09-01), None
Ahren, B.;Cholinergic and VIPergic Effects on Thyroid Hormone Secretion in the Mouse; Peptides;6:585-589 (1985).
Amenta, F., et al.;Cholinergic Nerves in the Thyroid Gland; Cell and Tissue Res.;195:367-370 (1978).
Aoki, K.R.;Preclinical Update on BOTOX®(botulinum Toxin Type A)-Purified Neurotoxin Complex Relative to other Botulinum Neurotoxin Preparations;Eur. J. Neurol; 6(Suppl 4):S3-S10; (1999).
Boyd, R.S., et al.;The Effect of Botulinum Neurotoxin-B on Insulin Release from a B-Cell Line; Movement Disorders;vol. 10, No. 3; Item 19; 376 (1995).
Boyd, R.S., et al.;The Insulin Secreting B-Cell Line HIT-15 Contains SNAP-25 Which is a Target for Botulinum Neurotoxin-A; Movement Disorders;vol. 10, No. 3; Item 20; 376 (1995).
Brandi, M.L., et al.;Interaction of VIPergic and Cholinergic Receptors in Human Thyroid Cell; Peptides;8:893-897 (1987).
Braverman, L.E. (Editor);Diseases of the Thyroid;Humana Press; p. 157 (1997).
Cardinali, D.P., et al.;Peripheral Neuroendocrinology of the Cervical Autonomic Nervous System; Brazilian J. Med. Biol. Res.;27(3):573-599 (1994).
Fauci, A.S., et al. (Editors);Harrison's Principles of Internal Medicine,14thEdition; McGraw-Hill (1998).
Garry, M.G., et al.;Evaluation of the Efficacy of a Bioerodible Bupivacaine Polymer System on Antinociception and Inflammatory Mediator Release; Pain;82(1);49-55 (1999).
Gonelle-Gispert, C., et al.;SNAP-25A AND-25B Isoforms are Both Expressed in Insulin-Secreting Cells and Can Function in Insulin Secretion; Biochem. J.;339:159-165 (1999).
Huffman, L.J., et al.;Muscarinic Modulation of the Vasodilatory Effects of Vasodilatory Effects of Vasoactive Intestinal Peptide at the Rat Thyroid Gland; Neuroendocrinology;53:69-74 (1991).
Lakomy, M., et al.;Acetylcholine Esterase Positive Nerves in Swine Thyroid; Z. mikrosk.-anat. Forsch., Leipzig100, 1, S. 34-38 (1986).
Laskawi, R., et al.;Up-to-Date Report of Botulinum Toxin Type A Treatment in Patients with Gustatory Sweating(Frey's Syndrome);Laryngoscope108; 381-384 (Mar. 1998).
Longley, R.S., et al.;Effect of the Parasympathetic System on Calcitonin Secretion; Clin Res;27:657A (1979).
Lopez-Muniz, A., et al.;Etude des terminaisons nerveuses au contact des cellules parafolliculaires de la thyroide; Annales d'Endocrinologie(Paris); 59:3-8 (1998).
Melander, A., et al.;Presence and Influence of Cholinergic Nerves in the Mouse Thyroid; Endocrinology;105(1):7-9 (1979).
Mercadante, S., et al.;Celiac Plexus Block: A Reappraisal; Regional Anesthesia and Pain Medicine;23(1):37-48 (Jan.-Feb. 1998).
Powell, E.M., et al.;Controlled Release of Nerve Growth Factor from a Polymeric Implant; Brain Res;515(1-2):309-311 (1990).
Rao, J.K., et al.;Implantable Controlled Delivery Systems for Proteins Based on Collagen—pHEMA Hydrogels; Biomaterials;15(5):383-389 (1994).
Ragona, R.M., et al.;Management of Parotid Sialocete with Botulinum Toxin; Laryngoscope109; 1344-1346 (Aug. 1999).
Schantz, E.J. et al.;Properties and Use of Botulinum Toxin and Other Microbial Neurotoxins in Medicine; Microbiological Reviews;vol. 56, No. 1; 80-99 (Mar. 1992).
Singh, B.R.;Critical Aspects of Bacterial Protein Toxins; Natural Toxins II;Plenum Press, New York; pp. 63-84 (1996).
Stern, J.E., et al.;Influence of the Autonomic Nervous System on Calcium Homeostasis in the Rat; Biol Signals;3:15-25 (1994).
Stern, J.E., et al.;Parasympathetic Control of Parathyroid Hormone and Calcitonin Secretion in Rats; Journal of the Autonomic Nervous System;48:45-53 (1994).
Stevens, P.D., et al.;Managing Chronic Pancreatitis Pain: A Block in Time; AJG;94(4):872-874 (1999).
Unger, J., et al.;Mechanism of Cholinergic Inhibition of Dog Thyroid Secretion In Vitro; Endocrinology;114:1266-1271 (1984).
Williams, G.A., et al.;Effect of the Parasympathetic System on Secretion of Parathyroid Hormone; Metabolism;vol. 34, No. 7; 612-615 (Jul. 1985).

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