Hydroxy substituted fused naphthyl-azoles and fused...

Details Hydroxy substituted fused naphthyl-azoles and fused... Hydroxy substituted fused naphthyl-azoles and fused...

2005-08-23

2005-08-23

Desai, Rita (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S427000

Reexamination Certificate

active

06933392

ABSTRACT:
Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

REFERENCES:
patent: 4690931 (1987-09-01), Wick et al.
patent: 4985424 (1991-01-01), Van Wijngaarden et al.
patent: 5296504 (1994-03-01), Stjernshchantz et al.
patent: 5352708 (1994-10-01), Woodward et al.
patent: 5422368 (1995-06-01), Stjernschantz et al.
patent: 5494928 (1996-02-01), Bös
patent: 5561150 (1996-10-01), Wichmann
patent: 5571833 (1996-11-01), Kruse et al.
patent: 5578612 (1996-11-01), Macor et al.
patent: 5646173 (1997-07-01), Bös et al.
patent: 5874477 (1999-02-01), McConnell et al.
patent: 5889052 (1999-03-01), Klimko et al.
patent: 5902815 (1999-05-01), Olney et al.
patent: WO 00/12475 (2000-03-01), None
patent: WO 01/85152 (2001-11-01), None
Wichmann, 1996, “preparation of indenopyrazole-N-alkanamines . . . ”, CAS:124:343294.
“Nonlinear regression using spreadsheets”, Wayne P. Bowen, et al., “Principles”-Trends in Pharmacological Sciences, no date, 5 pages.
“Method For the Synthesis of2-Unsubstituted Tryptamines”, I.I. Grandberg et al., Chem. Heterocycl. Compd. (English Transl.) 9, 196 (1973).
“Role of 5-HT2Aand 5-HT2Creceptors in the stimulus effects of hallucinogenic drugs II: reassessment of LSD false positives”, David Fiorella, Richard A. Rabin, and J.C. Winter, Psychopharmacology (1995) 121:357-363.
“Pyrrolo[3,2,1-ij]quinoline Derivatives, a 5-HT2cReceptor Agonist with Selectivity over the 5-HT2aReceptor: Potential Therapeutic Applications for Epilepsy and Obesity”, Methvin Issac et al., Bioorganic & Medicinal Chemistry Letters 10 (2000) 919-921.
“Binding to the Serotonin 5-HT2Receptor by the Enantiomers of 125I-DOI”, M. P. Johnson, A. J. Hoffman, D. E. Nichols, and C.A. Mathis, Neuropharmacology vol. 26, No. 12, pp. 1803-1806, (1987).
“Do Beta-Adrenoceptors and Serotonin 5-HT1AReceptors Have Similar Functions in the Control of Intraocular Pressure in the Rabbit?”, N. N. Osborne and G. Chidlow, Ophthalmologica (1996), 210:308-314.
“Some 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolines”, Edgar A. Steck (1a), and Lynn T. Fletcher (1b), with Clarissa D. Carabateas, Sterling-Winthrop Research Institute, Rensselaer, New York 12144, (Jun. 1974), pp. 387-393.
“Effect of 5-methylurapidil, an α1a-adrenergic antagonist and 5-hydroxytryptamine1aagonist, on aqueous humor dynamics in monkeys and rabbits”, Rong-Fang Wang, Ping-Yu Lee, Thomas W. Mittag, Steven M. Podos and Janet B. Serle, Department of Ophthalmology, Mount Sinai School of Medicine, New York, USA, Current Eye Research 16, 769 (1997), pp. 769-775.
“Effect of p-MPPI Hydrochloride (p-MPPI) Applied Before 5-Methylurapidil (5-MU) on Intraocular Pressure (IOP) in Normal Monkeys”, R-F Wang, Thom Mittag, S. M. Podos, J.B. Serle, Abstract 2236-B93, Department of Opthalmology, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY., p. S488.

Affiliated with

Also associated with

Rating

Hydroxy substituted fused naphthyl-azoles and fused... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxy substituted fused naphthyl-azoles and fused..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxy substituted fused naphthyl-azoles and fused... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3476675