Production of 3-hydroxypropionic acid in recombinant organisms

Details Production of 3-hydroxypropionic acid in recombinant organisms Production of 3-hydroxypropionic acid in recombinant organisms

2005-02-08

2005-02-08

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

C435S183000, C435S190000, C435S252300, C435S320100, C435S252330, C536S023200

Reexamination Certificate

active

06852517

ABSTRACT:
The production of 3-hydroxypropionic acid (3-HP) from glycerol in a bacterial host is described. 3-HP is a useful feedstock for the production of polymeric materials. The genetic engineering of a bacterial host with two enzymes is sufficient to enable production of 3-HP. One enzyme is a glycerol dehydratase and the other is an aldehyde dehydrogenase.

REFERENCES:
patent: 4962027 (1990-10-01), Slininger et al.
patent: 5164309 (1992-11-01), Gottschalk et al.
patent: 5254467 (1993-10-01), Kretschmann et al.
patent: 5413960 (1995-05-01), Dobrogosz et al.
patent: 5599689 (1997-02-01), Haynie et al.
patent: 5633362 (1997-05-01), Nagarajan et al.
patent: 5686276 (1997-11-01), Laffend et al.
patent: 6329183 (2001-12-01), Skraly et al.
patent: WO 9821340 (1998-05-01), None
patent: WO 9928480 (1999-06-01), None
Tang et al.,Immunochemical Properties of NAD+-Linked Glycerol Dehydrogenases from Escherichia coli and Klebsiella pneumoniae, 152, No. 3, J. Bacteriol. 1169-1174 (1982).
Barbirate et al.,Anaerobic pathways of glycerol dissimilation by Enterobacter agglomerans CNCM 1210: limitations and regulations, 143, Microbology 2423-2432 (1997).
Cameron et al.,Metabolic Engineering of Propanediol Pathways, 14 Biotechnol. Prog. 116-125 (1998).
Tong et al., 1,3-Propanediol Production byEscherichia coliExpressing Genase from theKlebsiella pnuemoniaedha Regulon, 57, No. 12, Appl. Environ. Microbiol. 3541-3546 (1991).
Tong and Cameron,Enhancement of 1,3-Propanediol Production by Cofermentation in Escherichia coli Expressing Klebsiella pneumoniae dha Regulon Genes, 34/35 Appl. Biochem. Biotechnol. 149-159 (1992).
Cameron and Tong,Cellular and Metabolic Engineering, 38, Appl. Biochem. Biotechnol. 105-140 (1993).
Skraly et al.Construction and Characterization of a 1,3-Propanediol Operon, 64, No. 1, Appl. Environ. Microbiol. 98-105 (1998).
Skraly and Cameron,Purification and Characterization of a Bacillus licheniformis Phosphatase Specific for D-α-Glycerophosphate, 349, No. 1, Archives of Biochem. Biophys. 27-35 (1998).
Skraly,Polyhydroxyalkannates Produced by Recombinant E. coli, Poster at Enginnering Foundation Conference: Metabolic Engineering, entire document (1998).

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