Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2005-08-02
2005-08-02
Wehbe, Anne M. (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S008000, C800S009000, C800S013000, C800S014000, C800S021000, C435S325000, C435S354000, C435S235100
Reexamination Certificate
active
06924415
ABSTRACT:
The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its role molecular events that lead to or contribute to cardiac hypertrophy and/or dilated cardiomyopathy. In particular, inhibition of MEK5 activity will lead to decrease signalling of the pathways and reduce or eliminate the effects on sarcomere assembly, which in turn result or contribute to cardiac dysfunction. Also provided are transgenic animals and methods of screening for inhibitors of MEK5.
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Nicol Rebekka
Olson Eric N.
Board of Regents , The University of Texas System
Fulbright & Jaworski LLP
Kelly Robert M.
Wehbe Anne M.
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