Humanized immunoglobulin reactive with B7-2 and methods of...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S130100, C424S133100, C424S141100, C424S143100, C424S144100, C424S173100, C435S069600, C435S252300, C435S320100, C435S326000, C435S328000, C435S332000, C435S334000, C435S343000, C435S343100, C435S346000, C435S440000, C435S455000, C530S387100, C530S387300, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C536S023100, C536S023400, C536S023500, C536S023530

Reexamination Certificate

active

06972125

ABSTRACT:
The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.

REFERENCES:
patent: 5397703 (1995-03-01), de Boer et al.
patent: 5562903 (1996-10-01), Co et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5622701 (1997-04-01), Berg
patent: 5624821 (1997-04-01), Winter et al.
patent: 5648260 (1997-07-01), Winter et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 5747034 (1998-05-01), de Boer et al.
patent: 5869050 (1999-02-01), de Boer et al.
patent: 6084067 (2000-07-01), Freeman et al.
patent: 94/01547 (1994-01-01), None
patent: 95/03408 (1995-02-01), None
patent: WO 96/14865 (1996-05-01), None
patent: 98/19706 (1998-05-01), None
Genes IV, Lewin et al., Oxford University Press, 1990, p. 810 only.
Azuma, M. et al., “B70 antigen is a second ligand for CTLA-2 and CD28,”Nature366:76-79 (1993).
Berzofsky, J.A. and Berkower, I.J., “Antigen-Antibody Interaction,” InFundamental Immunology, W.E. Paul eds. (NY: Raven Press), pp. 595-644. (1984).
Chen, L. et al., “Costimulation of Antitumor Immunity by the B7 Counter receptor for the Lymphocyte Molecules CD28 and CTLA-4,”Cell71:1093-1102 (1992).
Co, M. S. et al., “Chimeric and Humanized Antibodies with Specificity for the CD33 Antigen,”The J. of Immunology148 (4) :1149-1154 (1992).
Cole, M.S. et al., “Human IgG2 Variants of Chimeric Anti-CD3 Are Nonmitogenic to T cells,”The J. of Immunology159:3613-3621 (1997).
Daikh, D. et al., “The CD28-B7 costimulatory pathway and its role in autoimmune disease,”J. of Leukocyte Biol.62:156-162 (1997).
Ellison, J. and Hood, J., “Linkage and sequence homology of two human immunoglobulin in γ heavy chain constant region genes,”Proc. Natl. Acad. Sci. USA79:1984-1988 (1982).
Engel, P. et al., “The B7-2 (B70) Costimulatory Molecule Expressed by Monocytes and Activated B Lymphocytes Is the CD86 Differentiation anitgen,”Blood84(5) :1402-1407 (1994).
Fleischer, J. et al., “Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes,”Immunology89:592-598 (1996).
Fujihara, M. et al., “Decreased Inducible Expression of CD80 and CD86 in Human Monocytes After Ultraviolet-B Irradiation: Its Involvement in Inactivation of Allogenecity,”Blood87(6) :2386-2393 (1996).
Glaser, S.M. et al., “Dissection of the Combining Site in a Humanized Anti-Tac Antibody,”The J. of Immunology149(8) : 2607-2614 (1992).
He, X. -Y. et al., “Humanization and Pharmacokinetics of a Monoclonal Antibody with Specificity for Both E- and P-Selectin,”The J. of Immunology160:1029-1035 (1998).
Jeannin, P. et al., “CD86 (B7-2) on Human B Cells,”The J. of Biol. Chemistry 272(25) :15613-15619 (1997).
Jefferis, R. and Lund, J., “Molecular characterization of IgG antibody effector sites,”Department of Immunol., The Medical School, EDgbaston, Birmingham, pp. 115-126.
Levitt, M. “Molecular Dynamics of Native Protein,”J. Mol. Biol.168:595-620 (1983).
Morrisons, S.L. et al., “Complement activation and Fc receptor binding by IgG,” InProtein Engineering of Antibody Molecules for Prophylactic and Therapeutic Applications in Man, M. Clark, eds. (England: Academic Titles), pp. 101-113 (1993).
Ohki, O. et al., “Functional CD86 (B7-2/B70) is predominantly expressed on Langerhans cells in atopic dermatitis,”British J. of Dermatology136:838-845 (1997).
Queen, C. et al., “A humanized antibody that binds to interleukin 2 receptor,”Proc. Natl. Acad. Sci. USA86:1029-1033 (1989).
Reiser, H. and Schneeberger, E.E, “Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity,”Eur. J. Immunol. 26:880-885 (1996).
Reiser, H. and Stadecker, M.J., “Costimulatory B7 Molecules in the Pathogenesis of Infection Autoimmune Diseases,”Mechanisms of Disease335(18):1369-1377 (1996).
Rugtveit, J. et al., “Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflamatory bowel disease (IBD),”Clin. Exp. Immunol. 110:104-113 (1997).
Shalaby, M.R. et al., “Development of Humanized Bispecific Antibodies Reactive with Cytotoxic Lymphocytes and Tumor Cells Overexpressing the HER2 Protooncogene,”J. Exp. Med. 175:217-225 (1992).
Tempest, P.R. et al., “Reshaping A Human Monoclonal Antibody to Inhigit Human Respiratory Syncytial Virus Infection In Vivo,”Bio/Technology9:266-271 (1991).
Townsend, S.E. and Allison, J.P., “Tumor Rejection After Direct Costimulation of CD8+T Cells by B7-Transfected Melanoma Cells,”Science259:368-369 (1993).
Yokozeki, H. et al., “Functional CD86 (B7-B70) on Cultured Human Langerhans Cells,”The Society for Investigative Dermatology, Inc. 106:147-153 (1996).
Liu, Z-X., et al., “Increased Expression of Costimulatory Molecules on Peripheral Blood Monocytes in Patients With Crohn's Disease,”Scand J. Gastroenterol, 32(12) :1241-6 (1997).
Lisa A. Damico, et al., “Pharmacokinetics of IV Administered Murine Anti-Human B7.1 and Murine Anti-Human B7.2 in Cynomoglus Monkeys” Abstract, 17th Annual Scientific Meeting, Jan. 9, 1998.
Cromwell, M.A. and Goldman, S.J., Abstract: “The Human PBMC-Reconstituted Nod-Scid Mouse as model of Superantigen-Induced Human T Cell Activation,” Experimental Biology 98 Metting, Apr. 22, 1998.
Bluestone, J.A., “Costimulation and its role in organ transplantation,”Clinical Transplantation10:104-109 (1996).
Alegre, M-L. et al., Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors,Digestive Diseases and Sciences, 40(1):58-64 (1995).
Bree, A.G. et al., “Humanized anti-B7-1 and anti-B7-2 antibodies prevent antigen specific induction immunity in nonhuman primates immunized with tetanus toxoid and mumps virus vaccine,” Blood, 94(10) Suppl. 1 part 1, p. 439a (1999).
Hathcock, K.S. et al., “Role of the CD28-B7 costimulatory pathways in T cell-dependent B cell responses,”Advances in Immunology, 62:131-166 (1996).
Lenschow, D.J. et al., “Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse,”J. Exp. Med., 181:1145-1155 (1995).
Lenschow, D.J. et al., “Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies,”Transplantation, 60:1171-1178 (1995).
Wettendorff, M. et al., “Generation of humanized Fab fragments of B7-24 mAb, an antibody with potential use in the prevention of graft rejection and development of graft-versus-host disease,”Med. Fac. Landbouwkundige en toegepaste biologische, 60:2057-2063 (1995).
Co, M.S., et al., “Humanized Antibodies for Antiviral Therapy,”Proc. Natl. Acad. Sci. USA, 88:2869-2873 (1991).
Queen, C., et al., “A Humanized Antibody that Binds to the Interleukin 2 Receptor,”Proc. Natl. Acad. Sci. USA, 86:10029-10033 (1989).
Shalaby, M.R., et al., “Development of Humanized Bispecific Antibodies Reactive with Cytotoxic Lymphocytes and Tumor Cells Overexpressing theHER2Protooncogene,”J. Exp. Med., 175:217-225 (1992).
Tempest, P.R., et al., “Reshaping a Human Monclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection In Vivo,”Biotechnology, 9:266-271 (1991).

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