Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-12-20
2005-12-20
Gitomer, Ralph (Department: 1655)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C530S389200
Reexamination Certificate
active
06977159
ABSTRACT:
This invention provides a method of preventing or treating in a subject contact dermatitis which comprises administering to the subject an amount of a compound capable of inhibiting the stem cell factor signaling pathway effective to prevent or treat contact dermatitis so as to thereby prevent or treat contact dermatitis in the subject. This invention also provides a method of preventing or treating in a subject hyperpigmentation, asthma, cutaneous inflammation, anaphylaxis and bronchospasm, mastocytosis, tumors which express activated kit, and conception.
REFERENCES:
patent: 6576812 (2003-06-01), Longley
patent: 2002/0123031 (2002-09-01), Longley
Mohammadi M. Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors. Science. May 9, 1997, vol. 276, pp. 955-960.
Coleman J. Regulation of Mouse Peritoneal Mast Cell Secretory Function by Stem Cell Factor IL-3 or IL-4. J of Immunology Jan. 15, 1993, vol. 150, pp. 556-562.
Longley J. The Mast Cell and Mast Cell Disease. J Am Acad Dermatology Apr. 1995 32(4)545-561.
Columbo M. The Human Recombinant c-kit Receptor Ligand . . . J of Immunology Jul. 15, 1992, vol. 149(2)599-608.
Funasaka, Y. c-Kit Kinase Induces a Cascade . . . Molecular Biology of the Cell Feb. 1992 vol. 3 197-209.
Cooper & Dunham LLP
Gitomer Ralph
The Trustees of Columbia University in the City of New York
White, Esq. John P.
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