Thyroid receptor ligands

Details Thyroid receptor ligands Thyroid receptor ligands

2005-11-01

2005-11-01

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S132000

Reexamination Certificate

active

06960604

ABSTRACT:
The invention provides thiazolidinedione, oxadiazolidinedione, and triazolone compounds of Formula (I) which compounds are thyroid receptor ligands.The invention further provides pharmaceutical compositions and kits comprising such compounds and methods of treating obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer, diabetes, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesterolemia, depression, and osteoporosis using such compounds.

REFERENCES:
patent: 4069343 (1978-01-01), Sellstedt et al.
patent: 4554290 (1985-11-01), Böger et al.
patent: 4766121 (1988-08-01), Ellis et al.
patent: 4826876 (1989-05-01), Ellis et al.
patent: 4910305 (1990-03-01), Ellis et al.
patent: 5061798 (1991-10-01), Emmett et al.
patent: 5232947 (1993-08-01), Sato et al.
patent: 5284971 (1994-02-01), Walker et al.
patent: 5330999 (1994-07-01), de Nanteui
patent: 5401772 (1995-03-01), Yokoyama et al.
patent: 5569674 (1996-10-01), Yokoyama et al.
patent: 5654468 (1997-08-01), Yokoyama et al.
patent: 6008233 (1999-12-01), Andino et al.
patent: 0528734 (1993-02-01), None
patent: 0549365 (1993-06-01), None
patent: 0587377 (1994-03-01), None
patent: 0597102 (1994-05-01), None
patent: 0580550 (1997-10-01), None
patent: 04066579 (1992-03-01), None
patent: 8-59638 (1996-03-01), None
patent: 31660 (2001-02-01), None
patent: 2001 N031660 (2001-02-01), None
patent: WO9900353 (1999-01-01), None
patent: WO 9924415 (1999-05-01), None
patent: WO01/02377 (2001-01-01), None
patent: WO01/16123 (2001-03-01), None
Ebisawa, M. et al., Chem. Pharm. Bull., 47(9) 1348-1350 (1999), “Thiazolidinediones With Thyroid Hormone Receptor Antagonistic Activity”.
Ebisawa, M. et al., Biol. Pharm. Bull., 21(5), 547-549(1998), “Novel Thiazolidinedione Derivatives With Retinoid Synergistic Activity”.
Yokoyama, N. et al., J. Med. Chem. 1995, 38, 695-707, “Synthesis and Structure—Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to ι-Thyronine”.
Stephan, Z. F. et al., Atherosclerosis 126 (1996) 53-63, “Demonstration of Potent Lipid-Lowering Activity by a Thyromimetic Agent Devoid of Cardiovascular and Thermogenic Effects”.
Steele, R. E. et al., Atherosclerosis X, (1995), pp. 321-324, “CGS 26214, The Thyroxine Connection Revisited”.
Takamatsu Hideji,J. Pharm. Japan, vol. 76. No. 11—1956, pp. 1219-1222,Studies on Optically Active Phenylpropanolamine Derivatives. I Preparation of Optically Active alpha-Aminopropiophenones by Asymmetric Transformation.
Dow, Robert L. et al: “Benzyloxazolidine-2,4-diones as potent hypoglycemic agents” J. Med. Chem. (1991), 34(5), 1538-44, XP002093529.
De Nanteuil, G. et al: “Euglycemic and biological activities of novel thiazolidine-2,4-dione derivatives” Arzneim. -Forsch. (1995), 45(11), 1176-81, XP002037304.
Abstract of Japanese Patent (JP04066579A), (1992).

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