Polyoxometalate compounds as antiviral agents

Details Polyoxometalate compounds as antiviral agents Polyoxometalate compounds as antiviral agents

2005-06-28

2005-06-28

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

C424S604000, C424S617000, C252S389540, C423S053000, C423S594130, C423S606000, C562S562000, C562S560000, C548S344100

Reexamination Certificate

active

06911470

ABSTRACT:
Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas:in-line-formulae description="In-line Formulae" end="lead"?M7PW11O39in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M8SiW11O39in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M9HSiW9O34in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M8HPW9O34in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M10(TM)4(PW9O34)2in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M16(TM)4(P2W15O56)2in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M14[NaP5W30O110]in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M12(TM)3(PW9O34)2in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?M6P2W18O62in-line-formulae description="In-line Formulae" end="tail"?wherein M is an alkali metal, NH4+or other common monocation or soluble dication, or any combination of the above provided adequate water solubility is exhibited, or histidinium ion, argininium ion, or lysinium ion or any dication of a dipeptide or oligopeptide with 2 protonated basic amino acid residues, or any combination of these monocations or dications with each other or with any common inorganic cation, andTM is a divalent transition metal ion, such as Mn, Fe, Co, Ni, Cu and Zn.

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